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Drug Discovery

In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered.

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Academic high-throughput screening; Opportunities for change

9 April 2015 | By Tim Hammonds (Deputy Director of Discovery: CRT Discovery Laboratories)

Tim Hammonds from Cancer Research Technology Discoveries explains how academic HTS laboratories came into being and outlines the challenges facing the new HTS model...

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The impact of phenotypic and functional screening in CNS drug discovery

9 April 2015 | By Christine Williams (UCB), Wolfgang Fecke (UCB)

Wolfgang Fecke and Christine Williams from UCB discuss the industry’s approach to drug discovery with costs escalating and output failing to achieve the corresponding increases in revenue...

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Label-free technologies for monitoring drug interactions

9 April 2015 | By Jean-Francois Masson (Universite de Montreal and Centre for Self-Assembled Chemical Structures), Kristy McKeating (Universite de Montreal)

In his fascinating overview of label-free analysis, Dr. Masson introduces the four main label-free methods: physical, electrochemical, mass-based and optical techniques, before providing the reader with in-depth insight into the most common label-free technique within the pharmaceutical industry: surface plasmon resonance (SPR)...

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Evaluation of a GADD45a-GFP human cell assay for rapid and reliable in vitro early genotoxicity screening

9 April 2015 | By Anne-Pascale Luzy (Galderma R&D), Guy Bouvier (Galderma R&D), Jean-Michel Linget (Galderma R&D), Nicolas Orsini (Galderma R&D)

This article evaluates a GADD45a-GFP human cell assay for rapid and reliable in vitro early genotoxicity screening...

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The quest for accurate target validation

9 April 2015 | By Sheraz Gul (Fraunhofer-IME SP)

Preview of the upcoming foreword in our April issue, written by Sheraz Gul, Vice President and Head of Biology at Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Hamburg, Germany...

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The promise of induced pluripotent stem cells for liver disease, toxicology and drug discovery

9 April 2015 | By James Adjaye (Institute for Stem Cell Research and Regenerative Medicine), Nina Graffmann (Institute for Stem Cell Research and Regenerative Medicine), Peggy Matz (Institute for Stem Cell Research and Regenerative Medicine), Wasco Wruck (Institute for Stem Cell Research and Regenerative Medicine)

We discuss the steps required for differentiating human pluripotent stem cells into hepatocyte-like cells, and how long this process takes and the quality control measures needed...

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Workshop Review: Cell-based Assays for Screening (December 2014)

9 April 2015 | By Sheraz Gul (Fraunhofer-IME SP)

Sheraz Gul, Head of Biology at Fraunhofer-IME SP, provides an in-depth review of the Cell-Based Assays for Screening workshop which took place in December 2014...

news

PhoreMost Ltd founded to identify new druggable targets for therapeutics

7 April 2015 | By Victoria White

PhoreMost, a biopharmaceutical company focused on increasing diversity of novel therapeutics, has been founded to identify new druggable targets for cancer...

news

PeptiDream announces license of Peptide Discovery Platform System (PDPS) technology to Novartis

2 April 2015 | By Victoria White

PeptiDream Inc. has announced that Novartis has exercised its option to obtain a nonexclusive license to the Peptide Discovery Platform System technology...

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Merck Serono and Medicines for Malaria Venture sign agreement to develop potential antimalarial therapy

2 April 2015 | By Victoria White

Merck Serono and MMV have announced that an agreement has been signed for Merck Serono to obtain the rights to the antimalarial compound DDD107498...

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Consortium signs deal with Basilea to develop resistance-busting cancer drugs

1 April 2015 | By Victoria White

A consortium will collaborate with Basilea to progress a new family of cancer drugs designed to block several key cancer-causing proteins at once...

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Selvita initiates IND-enabling studies for its first-in-class PIM/FLT3 inhibitor

31 March 2015 | By Victoria White

Selvita announced today that it is commencing IND-enabling studies for SEL24 project, the company’s first oncology drug candidate...

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Invectys raises 1.7 million euros more to finance the clinical development of its therapeutic cancer vaccine

31 March 2015 | By Victoria White

Invectys has announced fundraising of 1.7 million euros from its original group of private investors, accelerating the clinical development of INVAC-1...

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Pfizer appoints Dr Charles Reay Mackay as Chief Scientific Officer, Inflammation and Immunology Research Unit

31 March 2015 | By Victoria White

Pfizer Inc. has announced that Charles Reay Mackay will join the company as Chief Scientific Officer for Pfizer’s Inflammation and Immunology Research Unit...

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CRT and BioInvent expand collaboration with University of Southampton to develop new immunotherapy treatments for cancer

30 March 2015 | By Victoria White

CRT and BioInvent have announced the start of a two-year research collaboration with leading antibody researchers at the University of Southampton...

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Drug Discovery