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DNA

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Novel method of labelling DNA bases developed for sequencing

19 May 2021 | By Victoria Rees (Drug Target Review)

Using electrochemical detection and redox labels, researchers have created a new, faster method to sequence DNA.

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Automated method to produce synthetic DNA created

13 May 2021 | By Victoria Rees (Drug Target Review)

Researchers have developed a technique to synthetically produce DNA oligonucleotides that avoids the degradation of phosphoramidites.

CRISPR method to restore Dystrophin protein

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Novel CRISPR strategy developed for Duchenne muscular dystrophy

12 May 2021 | By Victoria Rees (Drug Target Review)

A CRISPR gene editing technique has been developed to restore dystrophin, which is missing in many Duchenne muscular dystrophy (DMD) patients.

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Structure of DNA actively involved in genome regulation, study shows

10 May 2021 | By Victoria Rees (Drug Target Review)

Researchers have shown that topoisomerase TOP2A eliminates negative supercoiling, causing an increase in the number of turns of DNA strands and impacting gene expression.

Olink Article Finding a biomarker needle in the haystack

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Article: Finding a (biomarker) needle in the haystack

30 April 2021 | By Olink

Summary of a neurology publication by Alnylam Pharmaceuticals: large-scale protein screening identifies novel biomarker for onset and progression of lethal ATTRv amyloidosis.

news

Novel nanopore platform developed to sequence DNA

30 April 2021 | By Victoria Rees (Drug Target Review)

Scientists have created a new nanopore sequencing platform that can detect the presence of the nucleobases of DNA.

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New software could enable the design of DNA robots for drug delivery

20 April 2021 | By Victoria Rees (Drug Target Review)

Researchers have developed software that can design complex DNA nanodevices which could be used to deliver medicine while in the body.

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Scientists develop new CRISPR-based tool to control epigenome

19 April 2021 | By Victoria Rees (Drug Target Review)

Researchers have used CRISPR to create a new technology that can switch off almost any gene in cells, called CRISPRoff.

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Prime editing demonstrates success at precise gene editing in mice

31 March 2021 | By Victoria Rees (Drug Target Review)

Researchers have shown that prime editing is able to effectively edit genes in mice but without the off-target effects of CRISPR.

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Aptamer inhibits SARS-CoV-2 with novel mechanism of action, study shows

29 March 2021 | By Victoria Rees (Drug Target Review)

An aptamer that can bind a different part of SARS-CoV-2 than known inhibitors could enhance treatments against coronavirus mutations.

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Atomic force microscopy used to study endonuclease digestion of DNA nanostructures

2 March 2021 | By Victoria Rees (Drug Target Review)

A team of researchers have used microscopy techniques to monitor DNA degradation and anticancer drug release from nanostructures.

news

New bioinformatics tool accurately tracks synthetic DNA

1 March 2021 | By Victoria Rees (Drug Target Review)

A team has demonstrated that their bioinformatics approach, PlasmidHawk, can analyse DNA sequences to identify the source of engineered plasmids.

news

Researchers uncover insights into pioneer transcription factors

25 January 2021 | By Victoria Rees (Drug Target Review)

A research team has discovered how proteins called pioneer transcription factors turn on vital genes in cells.

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New probes shine a light on the role of four-stranded DNA in human cells

14 January 2021 | By Hannah Balfour (Drug Target Review)

A better understanding of the role of four-stranded DNA (G-quadruplex) could enhance cancer therapeutics, said the developers of the probes.

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New DNA-editing technique extends lifespan of mice with progeria

7 January 2021 | By Victoria Rees (Drug Target Review)

Researchers have used a novel DNA-editing method to convert one base pair to another, increasing the lifespan of mice with progeria.

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