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Disease research

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Metabolic modelling becomes three-dimensional

21 February 2018 | By Dr Zara Kassam (Drug Target Review)

An international research consortium has developed the first computer model to include 3D in the representation of human metabolic processes...

news

Calcium may play a role in the development of Parkinson’s

21 February 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers have found that excess levels of calcium in brain cells may lead to the formation of toxic clusters that are the hallmark of Parkinson's disease...

news

VILPs stimulate human cells to produce insulin-like hormones

20 February 2018 | By Dr Zara Kassam (Drug Target Review)

In an unexpected finding, scientists have identified four viruses that can produce insulin-like hormones that are active on human cells...

news

Microengineered intestinal lining mirrors living tissue inside organ-chip

19 February 2018 | By Dr Zara Kassam (Drug Target Review)

Microengineered Intestine-Chip has the potential to advance personalised treatments for gastrointestinal diseases...

news

New insights into alpha-synuclein function holds promise for Parkinson’s treatment

19 February 2018 | By Drug Target Review

Researchers have gained important insights into the role of alpha-synuclein – the protein associated with Parkinson’s disease – in nerve cells and how calcium affects its function. This knowledge is hoped to better arm scientists regarding future treatment for the disease.

news

New study directly links mossy brain cell activity to epilepsy symptoms

19 February 2018 | By Drug Target Review

New findings from an NIH-funded study of mice suggest that loss of mossy cells may contribute to seizures and memory problems in a form of epilepsy.

news

MeXis gene may protect against heart disease

16 February 2018 | By Dr Zara Kassam (Drug Target Review)

Scientists have identified a gene that may play a protective role in preventing heart disease...

news

CRISPR-Cas12a enables accurate disease diagnostics

15 February 2018 | By Dr Zara Kassam (Drug Target Review)

DETECTR system allows quick, one-step detection and diagnosis of disease, infection...

news

BX795 molecule clears HSV-1 infection in human corneal cells

15 February 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers at the have identified a small drug molecule that can clear the herpes simplex virus-1 infection, making it a promising potential option for patients who have developed resistance...

news

Osimertinib resistance explained by computer simulations

15 February 2018 | By Dr Zara Kassam (Drug Target Review)

Scientists have used molecular simulations to understand the resistance to osimertinib - an anticancer drug used to treat types of lung cancer...

news

Study uncovers molecular events that reveal pathway toward heart disease therapy

14 February 2018 | By Drug Target Review

Scientists from UNC-Chapel Hill and Princeton University in the United States, reveal key molecular details that hold promise for ultimate goal of heart disease reversal.

news

RT-QuIC assay adapted to test for Parkinson’s and dementia with Lewy bodies

14 February 2018 | By Dr Zara Kassam (Drug Target Review)

NIH scientists have modified an assay to offer the possibility of improving early diagnosis of Parkinson’s disease and dementia with Lewy bodies...

news

Huntington’s disease provides new cancer weapon

13 February 2018 | By Dr Zara Kassam (Drug Target Review)

Scientists have discovered why Huntington's is so toxic to cancer cells and harnessed it for a novel approach to treat cancer...

news

Small molecule could make a big difference for arthritis patients

13 February 2018 | By Drug Target Review

Scientists have discovered a molecule that enhances cartilage regeneration and decreases inflammation.

news

cDC1 cells could improve cancer immunotherapy

12 February 2018 | By Dr Zara Kassam (Drug Target Review)

Chemicals that attract specialised immune cells toward tumours could be used to develop better immunotherapies for cancer patients...

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