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Disease research

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Monoclonal antibodies produced by new cell lines hope to improve drugs

1 August 2018 | By Drug Target Review

Many biopharmaceutical companies look to produce biosimilars soon, since the patents on the original mAb expire over the next few years...

news

Research into cellular signalling mechanisms may lead to new treatments

31 July 2018 | By Drug Target Review

Wnt moves to specific areas of the cell membrane, interacting with a receptor known as Ror2, and inducing the formation of a cytoneme...

news

Novel antibiotics can be found on common weeds

31 July 2018 | By Drug Target Review

The team studied chemical compositions in detail and from one strain of bacteria several antibiotically active chemical substances were discovered...

news

IKZF1 gene could improve cancer immunotherapy

31 July 2018 | By Dr Zara Kassam (Drug Target Review)

A gene that's associated with an autoimmune form of hair loss could be exploited to improve cancer immunotherapy...

news

CMPK2 inhibitor could lesson symptoms of common illnesses

27 July 2018 | By Drug Target Review

CMPK2 inhibitors may reduce inflammation, pain and tissue damage in arthritis and gout and in Alzheimer’s may slow loss of cognitive function...

news

UBR5 protein may reduce neurodegeneration in Huntington’s disease

27 July 2018 | By Dr Zara Kassam (Drug Target Review)

Scientists have made an important step towards understanding the mechanisms that cause the neurodegenerative disorder Huntington's disease...

news

New drug for ALS ready for clinical trials

26 July 2018 | By Drug Target Review

Previous studies have suggested that a gene therapy drug may be used to treat ALS...

news

BCX7353 shows hope for hereditary angioedema

26 July 2018 | By Dr Zara Kassam (Drug Target Review)

A new drug has been developed to help prevent attacks of hereditary angioedema and at the same offer patients a convenient administration...

news

Blood test predicts the best treatment for prostrate cancer

26 July 2018 | By Drug Target Review

The study showed that patients testing positive for AR-V7 responded better to taxane-based chemotherapy and negative to hormone-targeted therapy...

news

Researchers identify new arthritis severity gene

26 July 2018 | By Dr Zara Kassam (Drug Target Review)

A new gene associated with disease severity in models of rheumatoid arthritis has been identified by...

news

Study suggests viral connection to Alzheimer’s disease

25 July 2018 | By Drug Target Review

A first-of-its-kind study implicates another culprit in the path to Alzheimer's disease: the presence of viruses in the brain...

news

Promising drug targets for t-cell lymphoblastic leukaemia

25 July 2018 | By Drug Target Review

Silencing the gene behind the production of HSP90, a target in the HSF1 pathway, effectively kills leukaemia cells, without affecting healthy cells...

article

Adapting drug discovery to Artificial Intelligence

25 July 2018 | By Ami S Lakdawala (GSK's In-silico drug discovery unit), George Okafo (GSK's In-silico drug discovery unit), John Baldoni (GSK's In-silico drug discovery unit), Michael Palovich (GSK's In-silico drug discovery unit), Tobias Sikosek (GSK's In-silico drug discovery unit), Vishal Sahni (GSK's In-silico drug discovery unit)

Drug discovery has always been challenging; today, more so than ever. While there has been success in addressing many diseases, others remain intractable...

news

How cannabis and cannabis-based drugs can harm your brain

24 July 2018 | By Dr Zara Kassam (Drug Target Review)

Long-term use of either cannabis or cannabis-based drugs impairs memory...

news

Recessive disorder impairing eyesight has been discovered

24 July 2018 | By Drug Target Review

Blindness in children has been linked to a recessive genetic disorder caused by the MARK3 gene...

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Disease research