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Digital 3D brain cell atlas released
The Blue Brain 3D atlas could be the future of analysing all cells in the brain, with high quality, high resolution images that can navigate the brain...
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Disease research
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High-throughput platform could map cancer drug target activity
Manchester University researchers have developed a high-throughput platform to analyse and study a family of enzymes that are linked to cancer...
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Application note: Integrated biologics – Enabling high-throughput drug discovery at Amgen with Thermo Fisher™ Platform for Science™ Software
Every day scientists are working to discover and develop new therapies and treatments to change the lives of patients suffering from serious and debilitating illnesses. Amgen Inc. has made it a priority to unlock the potential of biology to discover, develop, manufacture, and deliver innovative therapeutics to patients.
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Application note: A novel solution to expedite antibody discovery
With breakthroughs in molecular engineering and antibody humanisation, monoclonal antibodies (mAb) are one of the fastest-growing classes of biopharmaceuticals for multiple clinical indications including cancer, cardiovascular disease, autoimmune disorders and infectious disease. Most therapeutic antibody candidates are initially generated using hybridoma technology or primary B-cell screening after antigen immunisation.
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Starving lung cancer could be an effective treatment
A recently discovered enzyme could lead to the development of a treatment where cancer cells are starved of 'food' provided by this protein...
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Supercoils in DNA could give insights to antibiotic drug development
DNA gyrase, a molecular machine used to prevent DNA from coiling, could be used to ensure bacterial DNA coils, reducing the risk of infection to humans...
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Cryoablation could treat low risk breast cancer
A study by Princeton Radiology researchers has found that cryoablation could be effective in targeting low risk breast cancer...
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Mechanism could aid methods to combat immune attacks on the body
Chemical changes on mRNA were found to control the production of a protein called interferon beta, which could give insights on tackling immune diseases...
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Freeze-dried vaccine may help eradicate polio
Researchers have developed a polio vaccine that doesn't require refrigeration, meaning it could someday be used all over the world...
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slincR gene could shed light on chemical exposure effects in humans
The discovery of a new gene in zebrafish could lead to a better understanding of how exposure to chemicals leads to disease in humans...
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Transporting proteins into cells to mitochondria
J-proteins such as Xdj1, as helpers of the heat shock protein 70 chaperones, and were found to be involved in the transport of proteins to the mitochondria...
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Halting the spread of brain cancer
Mouse models used to show how convection enhanced delivery caused glioma cells to invade the rest of the brain could help to prevent this spread in future...
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Breast cancer recruits cells from bone marrow to boost growth
A study has shown that breast cancer uses stromal cells originally formed in bone marrow to boost their growth and metastasis of the cancer...
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MRI scans shows promise in predicting dementia
Brain changes evident in scans before memory, cognitive decline...
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Study reveals 35 genes linked to chronic kidney disease
A study conducted by researchers at The University of Manchester and Manchester Children's Hospital has revealed 35 genes linked to chronic kidney disease...
