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Bacteria compete for ‘ownership’ of human tissue
Research has shown how the same species of bacteria compete for space on human tissue, with researchers saying the mechanism could be used in research...
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Disease research
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Beyond ‘simple’ biology – turning organoids, spheroids, and 3D tissue models into physiologically relevant high-content assays for drug discovery
Drug discovery is still hampered by the routine use of cell-based models that often fail to recapitulate the truly relevant biological complexity of the corresponding disease. Just moving from two- (2D) towards three-dimensional (3D) cell culture model systems like spheroids and organoids is not enough to generate truly representative and…
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Repurposing wasp venom as antibiotic drugs
Researchers have used wasp venom to create variants of a peptide that is potent against bacteria but nontoxic to human cells...
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Phospholipid reactive T-cells could play a role in cancer
Phospholipid-reactive T-cells that are able to recognise phospholipids could help in treatments against cancer, autoimmune diseases and dyslipidemia...
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New imaging tools that trace key breast cancer enzymes may help guide therapies
Series of molecules may provide more reliable relief with fewer side effects...
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Omics-informed drug target discovery in combating emerging infectious diseases
The catastrophic consequences of ever-increasing rates of death from infectious diseases demands new experimental strategies for drug target selection and drug design. Over the last decade, the pharmaceutical industry has been wounded by several issues including failure of drug-development programmes, burgeoning cost of drug development, increasing regulatory control, lack of…
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Prolonging antibiotic potency by differentiating between resilience and resistance
Distinguishing whether bacteria are resistant to antibiotics or resilient to them is hugely important in determining the success of the treatment...
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Immunoassay developed to detect small molecules
An immunoassay developed to analyse small molecules has shown 50 times greater accuracy than current systems of analytical techniques...
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Pinpointing biopsies to detect and target cancer
Software that overlays tumour information from MRI scans onto ultrasound images could help to highlight areas of concern, and to detect and target cancer...
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Frizzled receptors could be drug targets for treating major diseases
Frizzled receptors, from the GPCR family, could soon be a target to treat numerous diseases such as cancer, fibrosis and CVD...
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Nanoscale ‘tweezers’ for individual cell biopsies
Researchers have developed nanoscale 'tweezers' used to investigate single living cells, which could help to identify why healthy cells become diseased...
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T-cells engineered to recognise tumours expressing the CD30 protein marker
Researchers have genetically engineered immune cells to recognise and fight Hodgkin and non-Hodgkin lymphoma cells...
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Genes linked to dementia identified
Nanoscientists have identified genes that link to dementia, in the hope that future therapies could target these genes for positive results in patients...
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ZFP64 protein is key to deadly blood cancer MLL
ZFP64, an inconspicuous MLL fusion protein was found to be neccessary for the production of MLL proteins, and could be targeted to inprove outcomes of MLL...
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Depleting ErbB4 gene alleviates Schizophrenia symptoms in new mouse models
Restoring brain cell receptors helps restore normal behaviour...
