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Disease research

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Direct link shown between inflammasome activation and Alzheimer’s

2 December 2019 | By Rachael Harper (Drug Target Review)

A new study has demonstrated that NLRP3 inflammasome directly drives tau pathology in neurodegenerative diseases and Alzheimer's disease.

news

Animal model market set to grow to $24bn by 2025

2 December 2019 | By Victoria Rees (Drug Target Review)

New research has found that the animal model market for disease research and therapeutic testing will exhibit strong growth.

news

Dengue vaccines may be improved by simulating amino acid starvation

28 November 2019 | By Rachael Harper (Drug Target Review)

Scientists have discovered that a plant-based compound called halofuginone activates a pathway that results in better antibodies and could improve the effectiveness of vaccines.

news

Fruit fly model to study mitochondrial diseases developed

28 November 2019 | By Drug Target Review

Researchers have created ‘three-parent flies' which can be used as a model to study mitochondrial diseases and screen potential drug compounds.

news

microRNA could lead to new methods to treat multiple sclerosis

27 November 2019 | By Rachael Harper (Drug Target Review)

In a pre-clinical model of multiple sclerosis, orally treating susceptible mice with a microRNA from the diseased gut has prevented the disease.

Mucin 6 gene indicates late-onset Alzheimer’s

news

Mucin 6 gene indicates predisposition to late-onset Alzheimer’s

25 November 2019 | By Mandy Parrett (Drug Target Review)

Scientists have idenified that variation in a gene called Mucin 6 appears to indicate a tendency for acquiring Alzheimer’s disease.

news

Inflammatory regulatory protein identified by researchers

22 November 2019 | By Victoria Rees (Drug Target Review)

A study has discovered that the PKM2 protein plays a role in regulating immune cells and blocking this could be a potential treatment for inflammatory diseases.

news

Better HIV, lupus and hep C treatments possible with malaria discovery

20 November 2019 | By Rachael Harper (Drug Target Review)

A new discovery on how the immune system responds to malaria infection could lead to better treatments for hepatitis C, HIV and lupus.

news

New molecular drivers of Parkinson’s disease uncovered

20 November 2019 | By Rachael Harper (Drug Target Review)

Molecular drivers of Parkinson's disease have been revealed by scientists who also determined how they impact the functions of genes involved in the condition and the results may point to potential new treatments.

news

ELRIG Drug Discovery 2019: looking back to the future

20 November 2019 | By Victoria Rees (Drug Target Review)

On 5-6 November, ACC Liverpool hosted the ELRIG Drug Discovery event, which allowed R&D professionals to come together and discuss the latest industry developments.

news

Researchers identify antibody that could treat pulmonary arterial hypertension

18 November 2019 | By Victoria Rees (Drug Target Review)

A study has revealed a new antibody that reverses the effects of pulmonary arterial hypertension in rodents and cell models.

news

Dysfunctional B cells found to contribute to age-related metabolic disease

18 November 2019 | By Victoria Rees (Drug Target Review)

A study has shown that a group of cells called adipose B cells can become dysfunctional with age, causing metabolic conditions such as diabetes, which has provided a drug target.

news

Phage therapy shows potential to treat alcoholic liver disease

14 November 2019 | By Rachael Harper (Drug Target Review)

Researchers have discovered that patients with alcoholic hepatitis had high numbers of a destructive gut bacterium and they were able to use a cocktail of phages to target and kill the bacteria, eradicating the disease.

news

Potential target found for tuberous sclerosis complex

14 November 2019 | By Rachael Harper (Drug Target Review)

A study on tuberous sclerosis complex has expanded the knowledge of the formation of this disease and how it can be targeted at the molecular level.

news

Potential treatment path shown for subtype of Charcot-Marie-Tooth disease

12 November 2019 | By Rachael Harper (Drug Target Review)

A new study could pave the way for developing a viable therapy for Charcot-Marie-Tooth patients affected by TyrRS mutations.

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Disease research