news Immune cells grown in dish from pluripotent stem cells 10 January 2020 | By Victoria Rees (Drug Target Review) In a world first, researchers have grown immune cells from pluripotent stem cells in a dish, which could be used to develop immunotherapies or to test autoimmune disease treatments.
news How dying cells prevent autoimmune reactions could inform treatments 9 January 2020 | By Hannah Balfour (Drug Target Review) The interaction between proteins on apoptotic cells and receptors of the murine immune system prevents autoimmune reactions and could be the basis for new treatments, according to scientists.
news HDAC3 inhibitors: a potential treatment for non-Hodgkin lymphomas? 9 January 2020 | By Hannah Balfour (Drug Target Review) A murine study found histone deacetylase 3 (HDAC3) inhibitors reverse epigenetic changes caused by CREBBP mutations found in lymphomas and could be developed into a novel therapy.
news Siah2 protein discovered as a regulator of the immune system 8 January 2020 | By Drug Target Review A new study has revealed that the Siah2 protein is crucial to control Tregs in mice, which can reduce the effectiveness of immunotherapies.
news Universal influenza vaccine protects mice against multiple strains of flu 8 January 2020 | By Hannah Balfour (Drug Target Review) A new double-layered nanoparticle vaccine protected mice against six strains of the flu and may provide the basis for the first universal vaccine against seasonal influenza, according to research.
news Blimp-1 identified as driver of T-cell activity against cancer 8 January 2020 | By Victoria Rees (Drug Target Review) A study has shown that T cells are driven to attack tumours by IL-2 and Blimp-1 in mice, which researchers say could form the basis of cancer therapies.
news Deleting body clock regulator gene BMAL1 protects mice against bacterial pneumonia 7 January 2020 | By Hannah Balfour (Drug Target Review) Deletion of the BMAL1 gene causes changes to the macrophage cytoskeleton, enhancing mouse model ability to combat bacterial pneumonia infection, according to new research.
news Syndecan-4 cell sensory protrusions activate hallmarks of cancer 7 January 2020 | By Hannah Balfour (Drug Target Review) A study has revealed that activation of syndecan-4 sensory protrusions extending from cells may be a future target for cancer therapy.
news Antibody HIV therapy for primate newborns shows potential as therapy 7 January 2020 | By Victoria Rees (Drug Target Review) A study has shown that administering two antibodies soon after birth can prevent HIV from developing in rhesus macaques.
news Computational model of molecular interactions could improve new medicine development 6 January 2020 | By Hannah Balfour (Drug Target Review) Researchers have produced a mathematical framework enabling quick assessment of how different parameters control interactions between molecules with multiple binding sites.
news Bile acids acting as inflammation regulators may protect against IBD 6 January 2020 | By Hannah Balfour (Drug Target Review) Research has found that bile acids, converted by gut microbes, act as inflammatory regulators in IBD by modulating the differentiation of T cells in the gut.
news Study identifies molecules to potentially treat Plasmodium parasites 6 January 2020 | By Victoria Rees (Drug Target Review) Researchers have discovered the most effective molecules to target DNA methylation from Plasmodium parasites, having shown success in pre-clinical trials.
news Activating c-Cbl gene causes immune system to attack cancer cells 3 January 2020 | By Hannah Balfour (Drug Target Review) Upregulation of the c-Cbl gene causes degradation of the immune checkpoint protein PD-1 and may provide a possible new avenue for cancer therapies, according to researchers.
news Researchers image C. diff toxins to aid in drug design 3 January 2020 | By Victoria Rees (Drug Target Review) A new study has used several imaging techniques to characterise C. diff toxins, which could help to design drugs to combat infections from the bacteria.
news Importin-11 identified as new therapeutic target for colorectal cancer 2 January 2020 | By Hannah Balfour (Drug Target Review) Researchers have discovered that Importin-11, a cell nucleus import protein, is required for colorectal cancer growth and may be a possible target for new therapies.
