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Disease research

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Structure of SARS-CoV-2 suggests reason for high infection rate, says study

7 May 2020 | By Victoria Rees (Drug Target Review)

Researchers have identified a structural loop in the SARS-CoV-2 S protein and a sequence of four amino acids that they say could help explain its high transmission rate.

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LAL assay derived from aquaculture could be used to detect endotoxins in human blood

7 May 2020 | By Victoria Rees (Drug Target Review)

Tests have shown that LAL assays produced from L. polyphemus in aquaculture often has a higher activity than lyophilised and preserved LAL from commercial kits.

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Researchers analyse SARS-CoV-2 genome, identifying 198 mutations

7 May 2020 | By Victoria Rees (Drug Target Review)

After analysing the genomic diversity in SARS-CoV-2 by screening over 7,500 viruses from infected patients, researchers have offered clues for COVID-19 drug development.

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Study finds activation sequence of COVID-19 S protein is cleaved by furin protease

6 May 2020 | By Victoria Rees (Drug Target Review)

Researchers have shown that the activation sequence the SARS-CoV-2 S protein is cleaved by the cellular enzyme furin which is also required for the infection of lung cells.

news

Immuno-oncology assay market predicted to be worth $6bn by 2026

6 May 2020 | By Victoria Rees (Drug Target Review)

A rise in biotechnology R&D activities is expected to drive the growth of the immuno-oncology assay market, with a CAGR of 10.6 percent.

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Unique mutation in SARS-CoV-2 virus identified from next-generation sequencing

5 May 2020 | By Victoria Rees (Drug Target Review)

Next-generation sequencing has revealed an 81-base pair mutation of the SARS-CoV-2 virus, which could be used to develop new antivirals or vaccines.

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Cytokine storms and T-cell counts may offer clues on COVID-19 treatment

4 May 2020 | By Victoria Rees (Drug Target Review)

According to a new study, treatments for COVID-19 should focus on cytokines and T-cell counts and their function, rather than patient respiratory function.

article

Intravenous immunoglobulins, hyperimmunes and pandemic viruses

4 May 2020 | By Hannah Balfour (Drug Target Review)

David Johnson of GigaGen discusses how recombinant forms of intravenous immunoglobulins (IVIG) could overtake current IVIG therapies and be used in the treatment of COVID-19.

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Researchers suggest COVID-19 therapeutics needed to target blood vessel leakage

1 May 2020 | By Victoria Rees (Drug Target Review)

According to researchers, ACE2 receptors disappear from lung cells during COVID-19, allowing small blood vessels to leak at the site of infection, presenting a new drug target.

COVID-19 particle and RNA strand outlined in blue on a black background

news

Collaboration to identify novel COVID-19 drug targets announced

30 April 2020 | By Hannah Balfour (Drug Target Review)

Bringing together protein science, drug discovery experience and innovative technology, a new collaboration aims to identify novel drug targets for COVID-19.

news

Antibodies developed from llama show promise in fighting COVID-19

30 April 2020 | By Victoria Rees (Drug Target Review)

Engineering antibodies found in a llama, researchers have developed a potential COVID-19 therapy which they say can neutralise SARS-CoV-2.

article

Developing respiratory therapeutics for prophylaxis and treatment

30 April 2020 | By Hannah Balfour (Drug Target Review)

Drug Target Review explores antiviral Fc-conjugates and how they could be used as a COVID-19 prophylactic and therapeutic with Dr Jeff Stein, Cidara’s President and CEO.

news

Scientists complete genomic study of herpes simplex virus

28 April 2020 | By Victoria Rees (Drug Target Review)

Researchers have unravelled the viral transcriptome and translatome of the herpes simplex virus (HSV-1) to aid disease research and immunotherapy.

hand holding a blood sample labelled 'covid-19' and a DNA strand, all in a grey-blue colour

news

NIAID releases strategic plan, outlining COVID-19 research priorities

28 April 2020 | By Hannah Balfour (Drug Target Review)

The US National Institute of Allergy and Infectious Diseases (NIAID) plan outlines four research priorities, including furthering understanding of SARS-CoV-2 viral transmission and pathogenesis and development of animal models.

article

Cytokine storms: a major killer in patients with severe COVID-19 infection

27 April 2020 | By Professor Saad Shakir (Drug Safety Research Unit)

Professor Saad Shakir explains why cytokine storms occur in COVID-19 patients and suggests potential therapies for the symptoms of the coronavirus.

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Disease research