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Researchers discover druggable pocket on SARS-CoV-2 Spike protein

22 September 2020 | By Victoria Rees (Drug Target Review)

A pocket in the SARS-CoV-2 Spike protein has been discovered by researchers, who say it could be a drug target for COVID-19.

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Literature review: A review to cross the hurdle of drug discovery with PROTACs

22 September 2020 | By Cisbio

This review highlights five recent publications about homogeneous assays applied to PROTACs, a chemical knockdown approach for cancer research.

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Application note: 3D image analysis and characterisation of angiogenesis in organ-on-a-chip model

22 September 2020 | By Molecular Devices

Many anti-angiogenic drugs have been developed to use in cancer therapy, while pro-angiogenic molecules may hold potential in regenerative applications.

variola poxviruses which cause human smallpox

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Lethal poxviruses could be rendered harmless with single gene removal

21 September 2020 | By Hannah Balfour (Drug Target Review)

Researchers report that removing the vSLFN gene from the ectromelia virus (ECTV) caused a potent immune response which protected animal models.

coronavirus particles surrounded by red blood cells

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4-PBA could prevent cytokine storm in severe COVID-19

21 September 2020 | By Hannah Balfour (Drug Target Review)

Scientists explore whether the anti-stress drug, 4-Phenylbutiric acid (4-PBA), could prevent cytokine storms causing respiratory failure in COVID-19 patients.

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ebook: Cellular Imaging Insights

21 September 2020 | By Molecular Devices

Learn how to gain insights and expedite studies for 2D and 3D cellular structures with affordable automated cellular imaging.

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Novel pseudo-virion probes to study SARS-CoV-2 viral entry

18 September 2020 | By Hannah Balfour (Drug Target Review)

The non-infectious quantum dot probes are designed to enable researchers to safely study interactions between the SARS-CoV-2 Spike (S) protein and human cells.

Lungs in red on a bright blue background

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Mystery glycoprotein could prevent respiratory distress

18 September 2020 | By Hannah Balfour (Drug Target Review)

According to researchers, the DMBT1S8 molecule can halt inflammation in the respiratory tract through its interaction with the Siglec-8 receptor on immune cells.

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ebook: Software compliance for GMP/GLP labs

18 September 2020 | By Molecular Devices

Achieve FDA 21 CFR Part 11 compliance with SoftMax® Pro GxP Software.

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On-demand webinar: Exploring absorbance-based assay applications: From virus to cannabis research

18 September 2020 | By Molecular Devices

Discover how absorbance detection works as well as different types of absorbance-based assay applications that scientists can utilise for their research.

Article Imaging dataset for COVID-19 research

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Article: Imaging dataset for COVID-19 research

18 September 2020 | By Molecular Devices

Molecular Devices helps Recursion produce the largest publicly available set of human cellular morphological data for COVID-19 therapeutic research.

brain with a cutaway of viral particles in orange surrounding a blue neuron - idea of viral encepalopathy

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A novel drug target for viral encephalitis therapies

17 September 2020 | By Hannah Balfour (Drug Target Review)

Researchers showed CXCL1 signalling to neutrophils drove brain inflammation in herpes simplex virus (HSV) encephalitis and blocking the protein resulted in less severe disease.

SARS-CoV-2 particles entering human cells

news

Could FDA-approved drug heparin prevent SARS-CoV-2 infection?

17 September 2020 | By Hannah Balfour (Drug Target Review)

SARS-CoV-2 entry into human cells is dependent on heparan sulfate and disrupting this interaction using heparin reduces infectivity of the coronavirus, find scientists.

Interactive demo Test drive the ImageXpress Pico Automated Cell Imaging System

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Interactive demo: Test drive the ImageXpress Pico Automated Cell Imaging System

17 September 2020 | By Molecular Devices

A powerful, yet affordable, high-content imaging system in your own lab.

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ebook: Get a front row view of your cells

17 September 2020 | By Molecular Devices

Discover how you can simplify your workflow by combining microplate reading and imaging in a small footprint.

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