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Disease research

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SARS-CoV-2 mechanism of infection revealed using cryo-electron microscopy

8 October 2020 | By Victoria Rees (Drug Target Review)

Researchers have found that the surface of SARS-CoV-2 can take on at least 10 different structural states when in contact with ACE2.

Syringe drawing liquid from a vial labelled 'REMDESIVIR', on a background of abstract SARS-CoV-2 particles [Credit: ffikretow@hotmail.com / Shutterstock.com].

news

Researchers identify a potential remdesivir resistance mechanism in SARS-CoV-2

8 October 2020 | By Hannah Balfour (Drug Target Review)

Exploring how the Ebola virus develops remdesivir resistance has highlighted a mutation that could allow SARS-CoV-2 to do the same.

webinar

SARS-CoV-2 testing: automation of high-throughput qPCR and COVID-seq

8 October 2020 | By SPT Labtech

In this on-demand webinar, we explored the various methods of COVID-19 testing: qPCR, COVID-seq, antigen and antibody detection, and others. Coupling these assays with low volume, high speed automation has made great strides toward achieving the high-throughput testing essential to ending this pandemic.

doctor holding a SARS-CoV-2 particle next to a picture of lungs

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Build-up in the lungs could be targeted by future severe COVID-19 treatments

7 October 2020 | By Hannah Balfour (Drug Target Review)

Breaking down or slowing the production of a hyaluronan jelly which builds up in the lungs of some severe COVID-19 patients could reduce respiratory distress and prevent death.

high tech, innovative biomedical research concept

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NIH to support 85 highly innovative research projects

7 October 2020 | By Hannah Balfour (Drug Target Review)

The US National Institutes of Health (NIH) will award a total of $251 million over five years to 85 high-risk, high-reward biomedical or behavioural research projects.

close up of a hepatitis C virus in a cutaway from a human liver

news

2020 Nobel Prize goes to discoverers of hepatitis C

6 October 2020 | By Hannah Balfour (Drug Target Review)

The 2020 Nobel Prize in Physiology or Medicine has been bestowed upon researchers who helped identify the hepatitis C virus in the 1970s.

news

New treatment could reverse vision loss caused by retinopathy

6 October 2020 | By Victoria Rees (Drug Target Review)

Researchers have developed an experimental compound that could treat vision loss in premature infants and adults.

Webinar Expanding assay applications with multi-mode readers from ELISA to AlphaScreen

whitepaper

Webinar: Expanding assay applications with multi-mode readers from ELISA to AlphaScreen

6 October 2020 | By Molecular Devices

Discover the multitude of avenues you can pursue with multi-mode microplate readers in your research.

Ovarian cancer cells forming a cancer spheroid as they grow within the peptide-protein co-assembling material [Credit: Alvaro Mata].

news

Novel tumour spheroids could improve ovarian cancer treatments

5 October 2020 | By Hannah Balfour (Drug Target Review)

Researchers have developed a new self-assembling three-dimensional (3D) ovarian cancer tumour model to recreate the in vitro disease more accurately.

Monitor mitochondria dynamics and phenotype with high-content imaging

whitepaper

Application note: Monitor mitochondria dynamics and phenotype with high-content imaging

5 October 2020 | By Molecular Devices

There has been growing interest in using high-content imaging methods for studying mitochondria.

SARS-CoV-2 - COVID-19 - inhibition by LY6E

news

Team identifies T-cell epitopes to inform COVID-19 vaccine development

2 October 2020 | By Victoria Rees (Drug Target Review)

Researchers studied 180 convalescent COVID-19 patients to reveal T-cell epitopes that they say can be targeted by a vaccine.

stand of DNA behing a side on view of the human head with the brain highlighted in red

news

Epigenetic marks could be the target of future Alzheimer’s therapies

2 October 2020 | By Hannah Balfour (Drug Target Review)

New findings suggest that late-onset Alzheimer's Disease (AD) is driven by epigenetic changes in the brain.

colourful SARS-CoV-2 particles surrounding a body shape with the lungs drawn in red

news

The NF-κB pathway drives fatal inflammation in COVID-19, say scientists

2 October 2020 | By Hannah Balfour (Drug Target Review)

Researchers found that the SARS-CoV-2 infection activates the NF-κB pathway, driving unchecked inflammation that contributes to total organ failure in COVID-19 patients.

Glioblastoma Multiforme (GBM) cells in culture [Credit: Dr Jin-Min Nam].

news

Identifying radioresistance drivers in glioblastoma multiforme

1 October 2020 | By Hannah Balfour (Drug Target Review)

According to researchers, Rab27b and epiregulin contribute to the development of radioresistance and could be targeted to improve glioblastoma patient survival.

news

Researchers identify mutations in single genes that lead to cerebral palsy

1 October 2020 | By Victoria Rees (Drug Target Review)

A new study has shown that the mutated FBXO31 and RHOB genes can each alone cause cerebral palsy, offering potential drug targets.

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Disease research