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Cell-based assays

woman with red open sores on her hand - idea of atopic dermatitis flare up

news

Study reveals novel targets for treating atopic dermatitis

12 January 2021 | By Hannah Balfour (Drug Target Review)

Understanding how Staphylococcus aureus bacteria colonises skin affected by atopic dermatitis could lead to new treatments that help prevent the spread of antibiotic resistance, say scientists.

3D rendering of pink villi with blue and green microbes - idea of microbiome of the human intestines

news

Novel intestine model could accelerate the development of treatments

8 January 2021 | By Hannah Balfour (Drug Target Review)

The transparent millifluidic perfusion cassettes (mPCs) developed by researchers should allow for better evaluations of the interactions between the cells and invading pathogens.

T cells in red attacking a white tumour/cancerous cell - idea of immunotherapies

news

NIK could be key to enhancing the effects of immunotherapy

6 January 2021 | By Hannah Balfour (Drug Target Review)

Immunology study shows that NF-kappa B-inducing kinase (NIK) is critical to T cell metabolism and the antitumour immune response.

cartoon of doctors looking at a lung diagram, stood next to a giant inhaler and a bottle of pills - idea of asthma/COPD treatment/drug development

news

Novel bronchodilator could be used for control of asthma

5 January 2021 | By Hannah Balfour (Drug Target Review)

Study identifies a promising new compound that can open constricted airways and could be a promising treatment for obstructive lung diseases.

Woman holding her swollen finger joints - idea of gout arthritis

article

Human 3D cell-based systems to research gout: drug discovery for a neglected disease

18 December 2020 | By Hannah Balfour (Drug Target Review)

In this article Andrew Nyborg from Horizon Therapeutics discusses why researchers are taking a second look at gout and how they are modelling the condition, which is unique to humans.

Glowing yellow pancreas in human torso - idea of diabetes, where pancreatic beta cells are destoryed

news

Next-generation diabetes prodrugs identified using novel screening platform

17 December 2020 | By Hannah Balfour (Drug Target Review)

Researchers engineered the Disque Platform, a high-fidelity culture system, to enable them to screen drugs able to promote β cell proliferation.

view of a human brain, left side bright pink, right side pastel pink, from the front - idea of neuroscience research

news

Brain organoids used to identify promising treatments for Rett syndrome

10 December 2020 | By Hannah Balfour (Drug Target Review)

Two drugs, Nefiracetam and PHA 543613, were able to return neuronal signalling to near normal in organoids derived from patients with the autism spectrum disorder, Rett syndrome.

surface of several coronavirus particles

news

Novel target could treat both SARS-CoV-2 and other coronaviruses

10 December 2020 | By Hannah Balfour (Drug Target Review)

Scientists shows targeting cholesterol or phosphatidylinositol phosphate (PIP) could be a promising strategy to combat multiple coronaviruses.

cartoon of blue coronavirus particles surrounding pink human lungs - idea of SARS-CoV-2 lung pathology

news

Researchers provide new insights into SARS-CoV-2 lung pathology

3 December 2020 | By Hannah Balfour (Drug Target Review)

The new study shows how SARS-CoV-2 significantly remodels cellular processes in just an hour and identifies potential drug targets and therapeutics for COVID-19.

news

Network modelling reveals a potential new Alzheimer’s therapy

25 November 2020 | By Hannah Balfour (Drug Target Review)

Researchers used integrative network biology analysis to identify the molecular mechanisms that may drive Alzheimer’s and identified a potential therapeutic intervention.

shape of a human brain constructed out of red coronavirus particles

news

SARS-CoV-2 can disrupt the blood-brain barrier, find scientists

2 November 2020 | By Hannah Balfour (Drug Target Review)

Binding of SARS-CoV-2 spike proteins to the brain’s endothelial cells can cause the blood-brain barrier to become leaky, potentially causing the neurological symptoms associated with COVID-19.

SARS-CoV-2 particles infecting a human cell

news

Lysosomes key to coronavirus shedding, finds study

29 October 2020 | By Hannah Balfour (Drug Target Review)

Scientists reveal that coronaviruses de-activate lysosomes before using them to exit infected cells and spread through the body.

heart on an abstract blue scientific background

news

Organs-on-a-chip model for breast cancer drug cardiac toxicity testing

27 October 2020 | By Hannah Balfour (Drug Target Review)

The newly developed chip includes heart and breast cancer tissues and could be used to predict the cardiac toxicity of chemotherapeutic drugs.

red viruses pouring out of pink human cell

news

Approved MS medication inhibits SARS-CoV-2 replication in vitro

5 October 2020 | By Hannah Balfour (Drug Target Review)

Dimethyl fumarate (DMF), a multiple sclerosis (MS) drug, inhibited SARS-CoV-2 replication and the hyper-inflammatory immune response associated with COVID-19.

Ovarian cancer cells forming a cancer spheroid as they grow within the peptide-protein co-assembling material [Credit: Alvaro Mata].

news

Novel tumour spheroids could improve ovarian cancer treatments

5 October 2020 | By Hannah Balfour (Drug Target Review)

Researchers have developed a new self-assembling three-dimensional (3D) ovarian cancer tumour model to recreate the in vitro disease more accurately.

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Cell-based assays