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Cell-based assays

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Targeting channel in cell lysosome could selectively kill cancer cells

25 October 2021 | By Anna Begley (Drug Target Review)

Activating the protein channel TRPML1 induced selective melanoma cell death while sparing normal cells, suggesting a potential pathway for new cancer therapies.

Cardiac proarrhythmic risk assessment using human-induced pluripotent stem cell-derived cardiomyocytes

webinar

Cardiac proarrhythmic risk assessment using human-induced pluripotent stem cell-derived cardiomyocytes

19 August 2021 | By Eurofins Discovery

Watch this on-demand webinar that discusses the two assays developed by Eurofins and why they represent a more physiologic and dynamic system to provide a more comprehensive pre-clinical model for cardiac liability assessment.

news

Scientists manipulate water droplets to create biochemical reactors

12 August 2021 | By Anna Begley (Drug Target Review)

Researchers have developed a new method that manipulates tiny water droplets in lab-on-chip applications for cell culturing and drug screening.

article

New models for intranasal drug delivery

6 August 2021 | By Dr Jon Lenn (MedPharm), Dr Jon Volmer (MedPharm)

In this article, Dr Jon Volmer and Dr Jon Lenn discuss a new approach to formulation models to test drug delivery based on reconstituted nasal epithelium.

news

Inhibiting PIP4K enzymes could help immune system fight cancer

27 July 2021 | By Anna Begley (Drug Target Review)

Researchers identified a potential therapeutic involving the inhibition of PIP4K enzymes which could enable the immune system to destroy tumour cells.

news

Screening method finds potential drugs to repurpose against COVID-19

13 July 2021 | By Anna Begley (Drug Target Review)

Researchers have identified 38 drugs that could be repurposed to treat COVID-19 through a strategy involving virtual screening and cell-based assays.

article

Making cell culture models more physiologically relevant

22 June 2021 | By Robert Skolik (University of Louisville)

A major limitation in drug development is the occurrence of drug-candidate toxicity during clinical research. This may occur because tumour-derived cell lines are limited as a pre-clinical model – in part because of an altered metabolic poise. A recent study has revealed a profound plasticity in gene expression and metabolic poise that can…

Automating functional cell-based bioassays: assay reproducibility and performance for potency testing programmes

webinar

Automating functional cell-based bioassays: assay reproducibility and performance for potency testing programmes

28 May 2021 | By Eurofins DiscoverX* and Tecan

In this on-demand webinar, we discuss how Eurofins DiscoverX’s off-the-shelf, MOA-based functional, cellular assays address these challenges, enabling drug discovery programmes up to late-stage development and market release.

news

Cell-based assays market set to exhibit CAGR of 8.5 percent

12 May 2021 | By Victoria Rees (Drug Target Review)

The global cell-based assays market is expected to grow due to increasing investments into cell-based research and a rise in chronic diseases.

article

COVID-19 drug targets and cell-based assays

30 March 2021 | By Alp Tegin Sahin (Kadir Has University), Sheraz Gul (Fraunhofer Institute)

The length of time between the administration of a COVID-19 vaccine and evidence of a robust immune response to Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) means that treatments are still required. In this article, Sheraz Gul and Alp Tegin Sahin explore the various therapeutic targets that have been identified…

article

Drug Target Review Assays ebook 2021

26 March 2021 | By Drug Target Review

In this ebook, find articles exploring some of the assays used to identify the most promising COVID-19 drugs and discussing the development of a novel assay to reveal potential peptide therapeutics for cancer.

news

Cell-based assays market set to be worth $22bn by 2025

24 March 2021 | By Victoria Rees (Drug Target Review)

New research has shown that the cell-based assays market will grow at a CAGR of 8.1 percent between 2020 and 2025.

news

Cell-based assay developed to identify IDO1 inhibitors for immuno-oncology

18 March 2021 | By Victoria Rees (Drug Target Review)

Researchers have developed a cell-based assay for the discovery of new IDO1 inhibitors, overcoming challenges from cell-free assays.

news

Nanolitre‐scale cell assays developed with droplet microarray-mass spec

16 March 2021 | By Victoria Rees (Drug Target Review)

A team has developed nanolitre cell assays on droplet microarrays to enable pharmacodynamic monitoring in live cells.

news

Novel enterocyte-like cells developed by researchers from stem cells

8 February 2021 | By Victoria Rees (Drug Target Review)

A team has developed enterocyte-like cells from hiPSCs, which can be used to study the absorption of novel oral drugs.

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Cell-based assays