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Antimicrobials

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CBD shown to kill Gram-negative bacteria in pre-clinical studies

20 January 2021 | By Victoria Rees (Drug Target Review)

Researchers have shown that CBD can kill Gram-negative bacteria, which could lead to the first new class of antibiotics for resistant bacteria in 60 years.

whitepaper

Whitepaper: Virus vaccine research – accelerated workflows

7 January 2021 | By PerkinElmer

Discover how workflows are being accelerated to speed up the vaccine research and development process while maintaining safety and immunogenicity.

various differently coloured lichen growing on a branch - the different colours are due to different biosynthetic pathways

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Identification of novel biosynthetic pathways in lichens could lead to new therapeutics

14 December 2020 | By Hannah Balfour (Drug Target Review)

Scientists have identified a new family of biosynthetic genes in lichens with unknown functions, which could produce new molecules for the pharmaceutical industry.

Jc Kay and a colleague wearing lab coats in a lab and looking at microbes in a petri dish

article

Antimicrobial resistance – a public health emergency on the horizon

2 December 2020 | By Nikki Withers (Drug Target Review)

Researchers at Ingenza and the University of Plymouth are using a machine learning and high‑throughput screening approach to discover novel antimicrobial therapies. In this article, Nikki Withers spoke to one of the researchers, Jack Kay, to hear about the current threat posed by antimicrobial resistance and how he hopes their…

article

Screening In-Depth Focus 2020

26 November 2020 | By Drug Target Review

In this in-depth focus find out how genetic screening can be used to customise healthcare and why scientists have turned to machine learning in the fight against antimicrobial resistance.

article

Drug Target Review – Issue 4 2020

26 November 2020 | By Drug Target Review

In this journal, find articles discussing antimicrobial resistance, exploring why inhibiting the interaction between SARS-CoV-2 and neuropilin-1 could help combat COVID-19, as well as how CRISPR can be used to enhance productivity in cell line development. Also in this issue, features on engineering new biologic drugs and precision medicine.

news

Simple molecule could combat antibiotic-resistant gonorrhoea and meningitis, study shows

25 November 2020 | By Victoria Rees (Drug Target Review)

An inexpensive molecule showed efficacy against antibiotic-resistant Neisseria gonorrhoeae and Neisseria meningitidis in an animal model.

Wasp on a wooden platform [Credit: University of Pennsylvania].

news

Novel antimicrobial molecules derived from wasp venom

13 October 2020 | By Hannah Balfour (Drug Target Review)

Altering the mastoparan-L (mast-L) peptide found in Vespula lewisii wasp venom, researchers created several novel antimicrobial molecules.

Syringe drawing liquid from a vial labelled 'REMDESIVIR', on a background of abstract SARS-CoV-2 particles [Credit: ffikretow@hotmail.com / Shutterstock.com].

news

Researchers identify a potential remdesivir resistance mechanism in SARS-CoV-2

8 October 2020 | By Hannah Balfour (Drug Target Review)

Exploring how the Ebola virus develops remdesivir resistance has highlighted a mutation that could allow SARS-CoV-2 to do the same.

news

Platform for hit-to-lead identification of antibacterial lysins developed

6 October 2020 | By Victoria Rees (Drug Target Review)

A group of scientists has created a novel high-throughput hit-to-lead development platform to identify engineered antibacterial lysins.

whitepaper

Webinar: Optimised workflow for rapid identification of neutralising antibodies against viral particles

24 September 2020 | By Molecular Devices

Helping in the race to identify effective neutralising antibodies against the spike protein of SARS-CoV-2 virus as the COVID-19 global death rate continues to rise.

news

Two compounds exhibit antibacterial properties against tuberculosis

31 July 2020 | By Victoria Rees (Drug Target Review)

Tested on two assays, researchers have shown that Redx03863 and Redx04739 can combat tuberculosis and do not lead to resistance.

American beautyberry shrub with purple berries in clusters and bright green leaves

news

Beautyberry leaf could be the secret to combatting MRSA infections

17 July 2020 | By Hannah Balfour (Drug Target Review)

A compound extracted from the leaf of the American beautyberry re-sensitised methicillin-resistant Staphylococcus aureus (MRSA) to beta-lactam antibiotics.

news

Approach to produce antibiotic compounds from actinobacteria developed

1 July 2020 | By Victoria Rees (Drug Target Review)

Researchers have created a method to promote the production of new antibiotic or antiparasitic compounds from the genomes of actinobacteria.

webinar

Drug repurposing approaches to fast track development of new therapies for COVID-19

26 June 2020 | By Tecan

This webinar described the recent efforts to identify small molecule therapeutics for the treatment of SARS-CoV-2 infection and COVID-19 disease.

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Antimicrobials