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Mouse models’ mimic lung disease
Researchers have finally been able to mimic IPF in mouse models - a debilitating disease, with no proper treatment and no cure...
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Genes increasing the risk of triple-negative breast cancer identified
Germ line genetic testing analyses blood samples and evaluates inherited genetic changes that increase the risk of certain cancers in an individual...
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Aortic plaques may contribute to liver disease progression
Aortic atherosclerotic plaque inflammation may contribute to the progression of non-alcoholic fatty liver disease to liver fibrosis...
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New stem cell model to test treatments for neurodegenerative disorders
The team found that astrocytes inhibit growth of precursor cells that become myelin, and speed up the neural network in the brain...
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Is acidity the weakness of cancer cells?
Cancer cells proliferating in alkalinity should be more vulnerable in acidic environments, so decreasing the pH may result in decreased proliferation...
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Monoclonal antibodies produced by new cell lines hope to improve drugs
Many biopharmaceutical companies look to produce biosimilars soon, since the patents on the original mAb expire over the next few years...
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Susceptible genes for childhood nephrotic syndrome identified
A specific haplotype was identified as having the highest risk of development, with another showing the lowest risk...
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CMPK2 inhibitor could lesson symptoms of common illnesses
CMPK2 inhibitors may reduce inflammation, pain and tissue damage in arthritis and gout and in Alzheimer’s may slow loss of cognitive function...
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Blood test predicts the best treatment for prostrate cancer
The study showed that patients testing positive for AR-V7 responded better to taxane-based chemotherapy and negative to hormone-targeted therapy...
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Adapting drug discovery to Artificial Intelligence
Drug discovery has always been challenging; today, more so than ever. While there has been success in addressing many diseases, others remain intractable...
article
Improving the translation of disease biology though phenomics
How times change. Up to 15 years ago, you would be hard-pressed to find a drug discovery conference with a track dedicated to phenotypic approaches. The underpinning science was called high-content imaging or analysis, being mainly confined to academic drug discovery labs and a handful of pioneers in industry. but…
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Urine tests are important in diagnosing myeloma
It may be better to examine the urine and the blood of patients suspected of tumours of the plasma cells...
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pGENMi predicts genomic features associated with drug responses
A new system, pGENMi, could predict genomic features associated with drug responses, by identifying differences in gene expression...
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Discovery of statistical method identifies cancer predisposition
New statistical method, ALFRED, could identify predisposition for cancers by using cancer genome data sets to identify risk variants.
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