article SARS-CoV-2, a spillover from animals to man, a spillback from man to animals and… what next? 9 September 2020 | By Professor Giovanni Di Guardo (University of Teramo) Professor Giovanni Di Guardo discusses the relationship between animals and humans in regards to the transmission of SARS-CoV-2.
news Study maps how COVID-19 infects various organs in the body 4 September 2020 | By Victoria Rees (Drug Target Review) By analysing the expression of 28 genes, researchers have been able to identify which organs are most vulnerable to infection from COVID-19.
news Genetic analysis of SARS-CoV-2 reveals one vaccine could combat all infections 2 September 2020 | By Victoria Rees (Drug Target Review) A genetic analysis of SARS-CoV-2 sequences reveal the virus has mutated minimally since December 2019, suggesting only one vaccine is needed to combat COVID-19.
news Inhibiting growth factor signalling prevents SARS-CoV-2 replication, report researchers 26 August 2020 | By Hannah Balfour (Drug Target Review) Scientists have patented their technique of inhibiting cellular growth factor signalling to stop SARS-CoV-2 replication and treat COVID-19.
news Tracking SARS-CoV-2 evolution: notable mutations and potential targets 26 August 2020 | By Hannah Balfour (Drug Target Review) Researchers report that while the spike protein and RNA polymerase proteins have stabilised, other regions of the SARS-CoV-2 genome are becoming increasingly variable.
news Two biomarkers of COVID-19 disease survival identified by researchers 25 August 2020 | By Victoria Rees (Drug Target Review) Scientists have revealed that the cytokines IL-6 and TNF-α are two biomarkers of inflammation that can predict the severity of COVID-19.
news AI holds promise to accelerate drug repurposing for COVID-19 20 August 2020 | By Victoria Rees (Drug Target Review) According to a new report, artificial intelligence (AI) is vital for the rapid identification of drugs that can be repurposed to combat COVID-19.
news Drug candidate outperforms remdesivir as COVID-19 antiviral in cell assays 18 August 2020 | By Victoria Rees (Drug Target Review) A compound called BOLD-100, which has shown efficacy against COVID-19 in pre-clinical trials, has now outperformed remdesivir in a cytopathic effect assay.
news Machine learning reveals potential COVID-19 therapeutic compounds 13 August 2020 | By Victoria Rees (Drug Target Review) A drug screen using machine learning has identified hundreds of potential drugs that could be used to treat COVID-19, researchers say.
news Atomic-scale details of SARS-CoV-2 Spike protein from vaccine obtained 11 August 2020 | By Victoria Rees (Drug Target Review) The SARS-CoV-2 Spike protein from a COVID-19 vaccine candidate has been characterised by researchers, supporting the neutralising antibody response it elicits.
news Five biomarkers revealed as indicators of COVID-19 patient survival 10 August 2020 | By Victoria Rees (Drug Target Review) Five immune response biomarkers have been identified by researchers who say they can be used to classify which COVID-19 patients will survive the disease.
news Largest sequencing study of SARS-CoV-2 presents six separate strains 6 August 2020 | By Victoria Rees (Drug Target Review) Researchers have sequenced SARS-CoV-2, revealing at least six strains with little variability, useful information for vaccine developers.
news Majority of T-cell targets not on COVID-19 Spike protein, study finds 31 July 2020 | By Victoria Rees (Drug Target Review) Research has shown T cells taken from patients with COVID-19 target the same three to eight immunodominant epitopes - most of which are not on the Spike protein.
news Functioning lung cell assay for modelling COVID-19 infections developed 31 July 2020 | By Victoria Rees (Drug Target Review) A UK company has announced that their lung epithelium model can successfully be used to test potential treatments for COVID-19.
news Team suggest bradykinin system could be targeted by COVID-19 drugs 29 July 2020 | By Victoria Rees (Drug Target Review) Researchers say computational analyses suggest the bradykinin system may explain some of the symptoms of COVID-19, providing a drug target.
