Simon Pearce

Rational drug design: How far have we come?

From the early use of Hansch parameters and Topliss Trees…

4 January 2018 | By Simon Pearce (Thermo Fisher Scientific)

From the early use of Hansch parameters and Topliss Trees to today’s computational structure–activity techniques, medicinal chemists have long sought to rationalise drug design to find the quickest and most resource-efficient route to market. But while modern strategies are more reliant on statistical algorithms and vast data libraries, these founding…