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The large family of pharmaceutical targets represented by G-protein coupled…
21 September 2015 | By Niklas Larsson (AstraZeneca), Torben Østerlund (AstraZeneca)
The large family of pharmaceutical targets represented by G-protein coupled receptors (GPCRs) are usually involved in a number of intracellular effector pathways, leading to many cellular outcomes. In recent years it has been uncovered that different ligands of a given GPCR may engage the pathways selectively, in that ligands that…
Although this target class is already heavily investigated, there are…
6 May 2014 | By Erik Ryberg (AstraZeneca R&D), Linda Sundström (AstraZeneca R&D), Lovisa Frostne (AstraZeneca R&D), Niklas Larsson (AstraZeneca R&D)
Although this target class is already heavily investigated, there are still a significant number of opportunities for discovery of novel drugs targeting additional GPCRs. In this review, scientists from AstraZeneca R&D discuss the general build-up of GPCR screening cascades for discovery of chemical leads that can be further developed into…
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