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Mindy Davis

 

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Enzymes: Ubiquitin-specific proteases as druggable targets

In much the same way that kinases and phosphatases attach…

21 September 2015 | By ,

In much the same way that kinases and phosphatases attach and remove phosphate groups from proteins to modulate their activity, there are a series of enzymes (E1, E2, E3) that add one or more ubiquitins onto a protein, as well as enzymes that remove them (deubiquitinases; DUBs), thereby regulating their…