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Researchers reveal how microbiome bacteria adapt through transmission

9 August 2021 | By Anna Begley (Drug Target Review)

Scientists have used genetic sequencing to demonstrate how the transmission of gut bacteria influences its evolution and functions, which could effect human health.

news

Therapeutic target for aggressive cancers discovered through CRISPR

5 August 2021 | By Anna Begley (Drug Target Review)

The RNA-modifying protein METTL1 could be targeted to treat some types of aggressive cancers, including brain, blood and kidney.

news

Inhibiting METTL3 enzyme combats acute myeloid leukaemia in mice

27 April 2021 | By Victoria Rees (Drug Target Review)

Scientists have developed a drug called STM2457 which inhibits a key enzyme involved in acute myeloid leukaemia.

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Alliance to create atlas of human genetic variants launched

6 April 2021 | By Victoria Rees (Drug Target Review)

The Atlas of Variant Effects Alliance will develop a map of human genetic variants to advance the understanding and treatment of disease.

news

Single cell analysis reveals sympathoblasts as target to treat neuroblastoma

8 February 2021 | By Victoria Rees (Drug Target Review)

Researchers have discovered that all childhood neuroblastomas come from sympathoblasts, making them a drug target to treat the condition.

news

Over 200 genes implicated in glioblastoma tumour growth

30 July 2020 | By Victoria Rees (Drug Target Review)

A study has identified more than 200 genes that drive the progression of glioblastoma and which the researchers say present drug targets.

news

Cell types enabling initial COVID-19 infection identified by researchers

27 April 2020 | By Victoria Rees (Drug Target Review)

An international group of researchers has revealed that goblet and ciliated cells in the nose have high levels of the entry proteins for the SARS-CoV-2 coronavirus.

news

UK Consortium to monitor spread and behaviour of coronavirus

24 March 2020 | By Hannah Balfour (Drug Target Review)

The UK government has invested £20 million into the COVID-19 Genomics UK Consortium, which will use whole genome sequencing to inform infection control measures and therapeutic developments.

news

Researchers generate atlas of thymus to understand T-cell development

25 February 2020 | By Victoria Rees (Drug Target Review)

A new study has created an atlas of human thymus development, to reveal which genes are needed for the production of specific T cells.

news

Root of childhood kidney cancer discovered

6 December 2019 | By Rachael Harper (Drug Target Review)

The earliest genetic root of Wilms' tumour has been discovered, which could not only lead to improved treatments but to one day being able to screen for cancers like this before tumours develop.

news

Regenerative medicine research boosted by stem cell discovery

4 June 2019 | By Victoria Rees (Drug Target Review)

A novel way to create Expanded Potential Stem Cells has generated opportunities to research regenerative medicine.

news

Strep A vaccine target identified for global use

30 May 2019 | By Victoria Rees (Drug Target Review)

Researchers use high-throughput DNA sequencing technology to identify a potential vaccine target for Strep A.

news

Immune regulators respond to parasite infections

1 February 2019 | By Drug Target Review

The master regulator that maintains a healthy gut and limits damage by parasitic whipworms has been identified as the interleukin 10 receptor...

news

Genetic study reveals possible new routes to treating osteoarthritis

23 January 2019 | By Dr Zara Kassam (Drug Target Review)

Scientists discover new genes and biological pathways linked to osteoarthritis, which could help identify starting points for new medicines...

news

Parasitic worm study predicts potential drug targets and drugs

6 November 2018 | By Iqra Farooq (Drug Target Review)

The largest ever parasitic worm study has revealed nearly 1 million new genes, and has identified potential drug targets and drugs...

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