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TEX264 protein could be targeted to help protect DNA from damage
Scientists have identified that the TEX264 protein and associated enzymes protect the genome from damage, which could lead to new anti-ageing and neurodegeneration therapies.
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Sheffield University
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Infrared light used to improve photodynamic therapy in model tumours
Researchers have developed a compound that can be activated with infrared light to kill cancer cells in model tumours, advancing the possibilities of photodynamic therapy.
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Researchers identify antibody that could treat pulmonary arterial hypertension
A study has revealed a new antibody that reverses the effects of pulmonary arterial hypertension in rodents and cell models.
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Researchers identify key mechanism of typhoid toxin
The process of Salmonella typhi to damage DNA has been revealed by researchers at the University of Sheffield which could inform treatments.
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Inflammation inhibitor could be used to treat sepsis
An inhibitor that stops the action of OGG1 signals, could potentially be used as a treatment for life-threatening Acute Respiratory Distress Syndrome...
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Derm-BOT compound relieves chronic pain
A modified form of botulinum toxin gives long-lasting pain relief in mice without adverse effects...
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Detecting diminished dopamine cells could reveal early signs of Alzheimer’s
A new link between diminished input from dopamine-firing cells could be crucial in detecting the earliest signs of Alzheimer's disease...
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Nine osteoarthritis genes discovered, paving way for new therapies
In the largest study of its kind, nine novel genes for osteoarthritis have been discovered...
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Scientists identify new treatment for Activated PI3-kinase Delta Syndrome
Scientists have identified a new treatment approach for patients with a rare inherited immune disorder...
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Fibromyalgia pathogenesis provides drug target clues
Fibromyalgia (FM) has been described as a condition of heightened generalised sensitisation to sensory input presenting as a complex of symptoms dominated by chronic widespread pain characterised by hyperalgesia and allodynia. A range of co-morbidities of variable intensity, such as fatigue, sleep disturbance, cognitive impairment, anxiety and depression, are often…
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Scientists discover bird blood cell which destroys C. neoformans
17 February 2016 | By Victoria White
Cryptococcus neoformans is a fungus that causes fatal infections in humans with a weakened immune system...
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Dasatinib shows promise in Duchenne muscular dystrophy
6 January 2016 | By Victoria White
Researchers tested the drug, commonly used to treat leukaemia, in zebrafish bred to carry Duchenne muscular dystrophy and recorded a 40% improvement in the condition of the fish...
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University of Sheffield appoints Cobra to advance growth hormone antagonist
23 November 2015 | By Victoria White
Cobra will be using its cell line development service, maxXpress, to produce the growth hormone antagonist fusion protein...
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Methotrexate could be repurposed to treat patients with blood cancers
6 July 2015 | By Victoria White
Scientists at the have discovered that a common drug given to arthritis sufferers, Methotrexate, could also help to treat patients with blood cancers...