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Longest successful gene expression raises hopes for gene editing therapies
A study has reported that genes delivered to rhesus monkeys are still being expressed four years later.
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Pennsylvania University
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Repurposing wasp venom as antibiotic drugs
Researchers have used wasp venom to create variants of a peptide that is potent against bacteria but nontoxic to human cells...
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Using anti-malaria drugs to slow tumour growth
Anti-malaria drugs, called chloroquines, target PPT1 from cancer cells, with researchers identifying how the drugs eliminate tumour growth in cancers...
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Tethered antibodies may prevent influenza virus infections
Investigational therapeutic candidate made with four antibodies tethered together shows promise against influenza A and B...
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RNA-seq of 20,000 cardiac cells reveals heart disease insights
RNA analysis of 20,000 cardiac cells from heart tissue in both ordinary and deceased mice showed an insight to the development of heart disease...
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Class of neurological disorders share 3D genome folding pattern
Researchers have found another common thread linking nearly all of the TNR expansion diseases...
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Research team develops predictor for immunotherapy response in melanoma
Researchers have developed a gene expression predictor that can indicate whether melanoma in a specific patient is likely to respond to treatment with immune checkpoint inhibitors...
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Brain cancer with mutation at EGFR alanine 289 may be susceptible to monoclonal antibody mAb806
Antibody mAb806 may be useful in treating aggressive forms of glioblastoma multiform...
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Researchers reveal therapeutic target for Influenza A
Researchers show altering the molecular interactions between the flu virus and host genes stunts virus replication...
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T cell populations in CLL patients indicate potential success of CAR-T cell therapy
Researchers have discovered the reason why some patients with advanced chronic lymphocytic leukaemia (CLL) don't respond to chimeric antigen receptor (CAR) T cell therapy...
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Scientists identify new stem cell that helps regenerate lung tissue after trauma
Researchers from the University of Pennsylvania have identified a lung stem cell that repairs the organ's gas exchange compartment, providing potential new approach to treat lung disease.
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Mouse study demonstrates that gut microbes protect against sepsis
A recent study at the University of Pennsylvania has identified that introducing particular microflora to the blood of mice increases immunoglobin A (IgA) levels, which appears to aid survival against sepsis.
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Effective drug transfer tests look promising for placenta-on-a-chip technology
Researchers in America have demonstrated the feasibility of their ‘placenta-on-a-chip’ platform in studying how drugs are transported across the human placental barrier.
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Study uncovers therapeutic targets for aggressive triple-negative breast cancers
New findings have made inroads into a strategy to identify TNBC tumours at risk for metastasis...
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Modulating FAP may impede pancreatic cancer
Researchers offer a promising target for future therapies that could potentially root out well-hidden metastatic cancer lesions...
