news Inhibiting METTL3 enzyme combats acute myeloid leukaemia in mice 27 April 2021 | By Victoria Rees (Drug Target Review) Scientists have developed a drug called STM2457 which inhibits a key enzyme involved in acute myeloid leukaemia.
news Bile duct organoids could be used as cell therapy for regenerative medicine 19 February 2021 | By Victoria Rees (Drug Target Review) For the first time, scientists have grown bile duct organoids that could repair damaged ducts and livers as a new cell therapy.
news Researchers discover how SARS-CoV-2 infects and replicates in host cells 9 November 2020 | By Victoria Rees (Drug Target Review) A team has revealed how SARS-CoV-2 infects cells, suggesting that targeting its RNA with drugs would stop the virus replicating.
news Developing drugs for disordered proteins 6 November 2020 | By Hannah Balfour (Drug Target Review) Scientists have developed a drug-like molecule to target amyloid-beta, a disordered protein implicated in Alzheimer's disease that has been considered undruggable.
news Over 200 genes implicated in glioblastoma tumour growth 30 July 2020 | By Victoria Rees (Drug Target Review) A study has identified more than 200 genes that drive the progression of glioblastoma and which the researchers say present drug targets.
news Open source all-atom model of entire COVID-19 S protein released 23 June 2020 | By Victoria Rees (Drug Target Review) Researchers have developed a video and model-building programme for other scientists to build full-length COVID-19 S protein models.
news Huntington’s update: optimal treatment times and implicated molecules 28 May 2020 | By Hannah Balfour (Drug Target Review) Two studies reveal the importance of timing in Huntington’s disease interventions and demonstrate interleukin-6 may play a protective role.
news Antibody for amyloid beta oligomers could revolutionise Alzheimer’s field 27 May 2020 | By Hannah Balfour (Drug Target Review) Scientists have designed a high affinity antibody for pathogenic amyloid beta oligomers, a key driver of Alzheimer’s disease, for use in further research and as a potential diagnostic tool.
news Fruit fly model to study mitochondrial diseases developed 28 November 2019 | By Drug Target Review Researchers have created ‘three-parent flies' which can be used as a model to study mitochondrial diseases and screen potential drug compounds.
news Whole genome sequencing could be used to improve cancer treatments 30 September 2019 | By Victoria Rees (Drug Target Review) Researchers have used whole genome sequencing to analyse breast cancers and reveal which are more responsive to treatments, which could improve the development of oncologic therapies.
news Process for rejuvenating aged rat brain stem cells discovered 14 August 2019 | By Fraser Owen (Drug Target Review) A research team has developed a method for regenerating old brain stem cells from rat models, which could be used to treat age-related brain diseases.
news ‘Ubiquitin clipping’ proteomics technique could be used as novel treatment 14 August 2019 | By Victoria Rees (Drug Target Review) A new technique called ‘ubiquitin clipping’ has been created which could aid proteomics research and the development of new drugs for ubiquitination.
news Human stem cell combination could help damaged hearts live longer 6 August 2019 | By Rachael Harper (Drug Target Review) A combination of heart cells derived from human stem cells could lead to developing a treatment for heart failure.
news Cause of MS damage in the brain identified 18 July 2019 | By Victoria Rees (Drug Target Review) A study has discovered that the damage of projection neurons in the brain is caused by immune cells, leading to MS.
news Molecule which targets Parkinson’s protein identified 6 June 2019 | By Victoria Rees (Drug Target Review) A new study has identified a molecule which targets a protein linked with Parkinson’s.
