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University College London (UCL)

Brain highlighted in orange surrounded my COVID-19 cells

news

Discovery unveils genetic risk factor shared by Alzheimer’s and COVID-19

12 October 2021 | By Anna Begley (Drug Target Review)

Scientists have identified the OAS1 gene as a risk factor for both Alzheimer's disease and COVID-19, suggesting potential drug targets.

news

Novel tool can estimate number of T cells in cancer tumours

10 September 2021 | By Anna Begley (Drug Target Review)

Researchers have developed a new method that can rapidly count the number of T cells in a tumour, helping to predict patient response to therapies.

news

Molecule in body that blocks antibody binding to SARS-CoV-2 discovered

23 April 2021 | By Victoria Rees (Drug Target Review)

Biliverdin attaches to a region of the SARS-CoV-2 Spike protein, stabilising it so that it is not able to expose its structure to antibodies, a new study has shown.

news

SARS-CoV-2 mutations do not increase transmissibility, research shows

30 November 2020 | By Victoria Rees (Drug Target Review)

Having analysed the SARS-CoV-2 genomes from over 46,723 patients, researchers have found no mutations that increase transmissibility.

cancer cell next to a DNA strnd, idea of cancer genetic mutations

news

Finding order in the chaos of cancer mutations

2 September 2020 | By Hannah Balfour (Drug Target Review)

Scientists observed that different cancers undergo the same genetic mutations at similar stages of evolution, the findings could become part of an ‘evolutionary rule book’ which would theoretically enable the prediction and prevention of cancer’s next evolutionary move.

dopaminergic neuron with cell body in pink and axon and dendrites in dark blue

news

Huntington’s update: optimal treatment times and implicated molecules

28 May 2020 | By Hannah Balfour (Drug Target Review)

Two studies reveal the importance of timing in Huntington’s disease interventions and demonstrate interleukin-6 may play a protective role.

neurons in purple surrounded by yellow protein aggregates - idea of Alzheimer's disease

news

Antibody for amyloid beta oligomers could revolutionise Alzheimer’s field

27 May 2020 | By Hannah Balfour (Drug Target Review)

Scientists have designed a high affinity antibody for pathogenic amyloid beta oligomers, a key driver of Alzheimer’s disease, for use in further research and as a potential diagnostic tool.

news

Researchers analyse SARS-CoV-2 genome, identifying 198 mutations

7 May 2020 | By Victoria Rees (Drug Target Review)

After analysing the genomic diversity in SARS-CoV-2 by screening over 7,500 viruses from infected patients, researchers have offered clues for COVID-19 drug development.

news

Increasing numbers of functional stem cells could improve transplants

27 March 2020 | By Hannah Balfour (Drug Target Review)

Exposing umbilical cord blood to NOV proteins causes an increase in functional haematopoietic stem cells (HSCs) and could provide a more effective transplant option for blood cancer patients.

news

Astrocytes could be harnessed to protect motor neurons in MND

11 February 2020 | By Hannah Balfour (Drug Target Review)

Scientists using a new motor neuron disease (MND) model have shown astrocytes may protect neurons from toxic TDP-43 protein aggregates in the early stages of disease.

cell with its internal contents visible undergoing autophagy

news

Immune cell autophagy discovery could optimise cancer therapies

23 January 2020 | By Victoria Rees (Drug Target Review)

Researchers reveal importance of IL-15 in T cell autophagy in the liver, presenting a potential strategy to enhance immunotherapies.

news

Blimp-1 identified as driver of T-cell activity against cancer

8 January 2020 | By Victoria Rees (Drug Target Review)

A study has shown that T cells are driven to attack tumours by IL-2 and Blimp-1 in mice, which researchers say could form the basis of cancer therapies.

news

Molecules associated with NMDAR may be involved in schizophrenia

18 January 2019 | By Dr Zara Kassam (Drug Target Review)

Genetic variants which prevent a neurotransmitter receptor from working properly have been implicated in the development of schizophrenia...

news

Pinpointing biopsies to detect and target cancer

6 December 2018 | By Drug Target Review

Software that overlays tumour information from MRI scans onto ultrasound images could help to highlight areas of concern, and to detect and target cancer...

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University College London (UCL)