news DNA vaccine protects non-human primates against MERS, study shows 23 April 2021 | By Victoria Rees (Drug Target Review) A candidate vaccine has shown potential against MERS in non-human primates, when administered intradermally.
news RNA protein shown to protect telomeres and support cancer proliferation 15 March 2021 | By Victoria Rees (Drug Target Review) A team has revealed a function of ADAR1, responsible for RNA editing, discovering an isoform used for cancer growth, making it a drug target.
news Inhibiting acetate metabolism shows promise in breast cancer model 8 January 2021 | By Hannah Balfour (Drug Target Review) Inhibiting the ACSS2 enzyme with a molecule called VY-3-135 caused a significant reduction in the growth of breast cancer tumours in vivo.
news Anticancer activity delivered by targeting mitochondrial cell regulator 4 October 2019 | By Rachael Harper (Drug Target Review) Disruption of the MFF-VDAC1 complex could lead to a potential therapeutic target for cancer.
news Potential EBV-associated cancer treatment in small molecule inhibitors 7 March 2019 | By Iqra Farooq (Drug Target Review) A small molecule inhibitor has been observed to activate a dramatic reduction in tumour growth in EBV-associated tumours...
news Protection against Mayaro virus using engineered DNA vaccine 8 February 2019 | By Drug Target Review An engineered DNA vaccine that induces a robust and specific immune response against the disease, also provides complete protection...
news DNA anticancer vaccine targets tumour neoantigens 24 January 2019 | By Iqra Farooq (Drug Target Review) A DNA vaccine developed through the use of unique tumour antigens could lead the way towards vaccinating people against cancer...
news PCSK9 inhibitors to treat high cholesterol 16 November 2018 | By Drug Target Review Low-density lipoprotein cholesterol could be treated by using synthetic DNA-encoded monoclonal antibodies to inhibit PCSK9...
news DNA vaccine shows promise for cancer immunotherapy 28 September 2018 | By Dr Zara Kassam (Drug Target Review) DNA vaccine optimised to cross-react with several MAGE-A isoforms generates a robust immune response and antitumour activity in a pre-clinical model of melanoma...
news Pro72Arg gene variant increases tumour cell metabolism 1 March 2018 | By Dr Zara Kassam (Drug Target Review) Scientists have found a mechanism through which mutant p53 enhances metastasis by controlling tumour metabolism...
news Mechanism identified of impaired dendritic cell function that weakens response to cancer 15 December 2017 | By Dr Zara Kassam (Drug Target Review) New research explains how accumulation of chemically modified lipids interferes with the function of a protein involved in the antitumor function of dendritic cells...
news DNA-based Zika vaccine found effective at inducing immune response 5 October 2017 | By Dr Zara Kassam (Drug Target Review) A new generation DNA-based Zika vaccine is the first to demonstrate both safety and the ability to elicit an immune response against Zika in humans...
news B-cells promote melanoma progression and resistance to therapy 21 September 2017 | By Dr Zara Kassam (Drug Target Review) Depletion of B cells in the tumour micro-environment shows anti-tumour activity in patients with advanced metastatic melanoma...
news Novel immunotherapy technology for prostate cancer 18 August 2017 | By Dr Zara Kassam (Drug Target Review) Scientists have described a novel immunotherapeutic strategy for the treatment of cancer based on the use of synthetic DNA...
news New therapeutic approach for ovarian cancer identified 24 July 2017 | By Dr Zara Kassam (Drug Target Review) Scientists discover, a potential new therapeutic strategy for a difficult-to-treat form of ovarian cancer...
