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Structure of DNA actively involved in genome regulation, study shows
Researchers have shown that topoisomerase TOP2A eliminates negative supercoiling, causing an increase in the number of turns of DNA strands and impacting gene expression.
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Spanish National Cancer Research Centre (CNIO)
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CRISPR used to eliminate cancers caused by fusion genes
Using CRISPR to cut out fusion genes, scientists were able to specifically induce cancer cell death in murine models of sarcoma and leukaemia.
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Researchers launch a collaborative brain metastases research platform
The Brain Metastasis Cell Lines Panel compiles research from various international institutions on the numerous brain metastasis cell lines that have been developed, in hopes collaboration will expedite research and drug development.
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Discovery of markers that predict evolution of triple-negative breast cancer
Researchers in Spain have identified a means of classifying patients with the most aggressive form of breast cancer - triple negative breast cancer; providing meaningful prognosis for the first time.
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A new therapy proves effective against brain metastasis
The administration of silibinin in patients with brain metastasis reduces lesions without causing any adverse effects, according to a study led by researchers at the Spanish National Cancer Research Centre (CNIO).
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Novel curative gene therapy treatment for pulmonary fibrosis in mice
Researchers in Spain have developed a method of gene therapy that cures pulmonary fibrosis in mice by lengthening telomeres – the protective protein sections at the end of chromosomes.
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Elimination of c-Raf kinase induces regression of advanced lung tumours
A study has shown how the elimination of the c-Raf kinase by genetic manipulation causes the regression of Kras oncogene-driven advanced lung tumours...
