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Metastasis-preventing drug target for pancreatic cancer identified
A protein called PPP1R1B has been revealed as a drug target for pancreatic cancer as it stopped the metastasis of tumours in mice.
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Sanford Burnham Prebys Medical Discovery Institute
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High-throughput screening reveals 21 drugs with activity against COVID-19
After screening 12,000 existing drugs, scientists have identified 21 which prevent the replication of SARS-CoV-2 in concentrations safe for patients.
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Vitronectin could be a promising drug target for macular degeneration
Scientists demonstrate that vitronectin is responsible of the formation of deposits in dry age-related macular degeneration and suggest inhibitors could slow disease progression.
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Siah2 protein discovered as a regulator of the immune system
A new study has revealed that the Siah2 protein is crucial to control Tregs in mice, which can reduce the effectiveness of immunotherapies.
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Five recent drug target discoveries for pancreatic cancer
This article highlights some of the most recent drug target discoveries that could be used to develop and design a treatment for pancreatic cancer.
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Machine-learning algorithm developed to aid in epigenetic drug discovery
A machine-learning algorithm has been created that automates high-throughput screens of epigenetic medicines.
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Study offers new approach to starve p53 deficient tumours
Sanford Prebys Medical Discovery Institute (SBP) researchers recently discovered an alternative metabolic pathway that might be used by cancer cells to survive nutrient deprivation.
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Study unearths how PKC zeta impacts colorectal cancer
Scientists in the United States have investigated the relationship between tumour suppressor, protein kinase C zeta (PKC zeta), and metastatic colorectal cancer.
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New research heralds future drug discovery pathways for hyperaldosteronism
A team of scientists in the United States has identified a mechanism that explains the development of hyperaldosteronism. These findings offer a potential path for drug discovery to treat the condition, which often leads to secondary hypertension.
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SORLA protein protects against Alzheimer’s disease
Researchers have identified a new protective function for a brain protein genetically linked to Alzheimer's...
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Novel system developed to improve cancer detection
Researchers have developed a proof-of-concept nano-system that dramatically improves the visualisation of tumours...
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How the anthrax toxin forms a deadly “conveyer belt”
28 September 2016 | By Niamh Louise Marriott, Digital Content Producer
During anthrax infections, the bacterium Bacillus anthracis secretes a toxin consisting of two related enzymes named lethal factor and edema factor...
