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Cyclisation reaction enables screening of macrocyclic compounds libraries
Libraries of more than 9,000 macrocyclic molecules below 1 KDa have been generated, small enough to cross cell membranes and reach targets.
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Ecole Polytechnique Fédérale De Lausanne
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Double-bridged peptides bind any disease target
Researchers have developed a new peptide format that they call double-bridged peptides...
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Disrupting macrophage action aids melanoma immunotherapy success
Scientists in Switzerland have uncovered a potential means of increasing effective treatment of melanomas with immunotherapy, by disrupting the action of macrophages.
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Researchers uncover the origins of leprosy and reason for its drug resistance
Scientists in Switzerland have developed the tools to sequence genes from the leprosy bacterium, Mycobacterium leprae, revealing information about its origins and reasons behind its resistance to drugs.
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Alzheimer’s Tau protein forms toxic complexes with cell membranes
Researchers identify the sequence and structural factors that drive Tau interaction with membranes...
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Metabolism can be used to subtype hepatoblastoma
Scientists have identified new biomarkers that could help more accurately classify the two main subtypes of hepatoblastoma...
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New method developed for 3-D imaging
Scientists have developed a microscopy method that generates fast and reliable 3D images of curvilinear structures...
