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Columbia University Vagelos College of Physicians and Surgeons

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Exome sequencing reveals genetic drug target for OCD

29 June 2021 | By Victoria Rees (Drug Target Review)

Following a whole exome sequencing study, researchers have found that mutations in the SLITRK5 gene could be targeted by drugs to treat OCD.

news

Endosomal trafficking could be a target for Alzheimer’s therapies

26 November 2020 | By Hannah Balfour (Drug Target Review)

Researchers have shown that 70 percent of Alzheimer’s patients have high levels of proteins associated with dysfunction in the endosomal trafficking system in their spinal fluid.

Blue antibodies surrounding a black SARS-CoV-2 particle with red Spike proteins on its surface

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Children produce a different antibody response to SARS-CoV-2 infection, finds study

6 November 2020 | By Hannah Balfour (Drug Target Review)

A new analysis reveals that the course of SARS-CoV-2 infection and the immune response it provokes is completely different in adults and children.

Golden DNA strand disintegrating on a black background

news

CRISPR editing can result in whole chromosome elimination, say scientists

2 November 2020 | By Hannah Balfour (Drug Target Review)

In a new study, scientists identify some of the pitfalls when using CRISPR Cas9 to correct mutations in human embryos, such as the destruction of whole chromosomes.

red blood cells being restricted in a blood vessel by its bulging walls caused by atherosclerosis

news

Putrescine could be a therapy for chronic inflammatory diseases

31 January 2020 | By Hannah Balfour (Drug Target Review)

Research has identified that putrescine, which aids macrophages in clearing dead cells, is lacking in atherosclerosis animal models and could be a potential therapeutic for the condition.

news

Succinate in cystic fibrosis lungs feeds deadly bacteria

23 August 2019 | By Rachael Harper (Drug Target Review)

Targeting a deadly bacteria's use of succinate in the lungs could control infection and improve the health of people with cystic fibrosis.

news

New technology provides process for precise gene editing

13 June 2019 | By Victoria Rees (Drug Target Review)

Researchers have presented their new technology for accurately inserting genes into the genome without cutting DNA.

news

IKZF1 gene could improve cancer immunotherapy

31 July 2018 | By Dr Zara Kassam (Drug Target Review)

A gene that's associated with an autoimmune form of hair loss could be exploited to improve cancer immunotherapy...

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Columbia University Vagelos College of Physicians and Surgeons