news Exosome formulation developed for choroidal neovascularisation therapy 27 July 2021 | By Anna Begley (Drug Target Review) An exosome formulation has been created to deliver vascular endothelial-growth factor (VEGF) antibodies for choroidal neovascularisation therapy in models.
news Non-invasive optical method could provide insight into brain diseases 19 July 2021 | By Anna Begley (Drug Target Review) A non-invasive, label-free optical method can produce high-resolution imaging of cellular brain diseases in vivo.
news Newly designed tumour vaccine could prevent cancer recurrence 9 July 2021 | By Anna Begley (Drug Target Review) Scientists have used nanotechnology to develop personalised tumour vaccines which prevented cancer recurrence and metastasis challenges in mouse models.
news Raman technique developed for high-throughput discovery of enzymes 10 August 2020 | By Victoria Rees (Drug Target Review) A flow mode Raman-activated cell sorter called FlowRACS has been created by researchers for high-throughput discovery of enzymes and their cell factories.
news Proteomic map of human lung adenocarcinoma revealed 13 July 2020 | By Hannah Balfour (Drug Target Review) The proteomic map based on data from 103 patients reveals novel prognostic biomarkers and potential drug targets for lung adenocarcinoma.
news Researchers reveal cryo-EM structure of remdesivir bound to SARS-CoV-2 4 May 2020 | By Victoria Rees (Drug Target Review) A group of researchers has used cryo-EM to discover the structure of the remdesivir-bound RNA complex of SARS-CoV-2 and explain how the drug inhibits COVID-19 viral replication.
news Lead SARS-CoV-2 inhibitor compound identified by researchers to treat COVID-19 23 April 2020 | By Victoria Rees (Drug Target Review) Researchers have found a lead compound which they say inhibits SARS-CoV-2 viral replication and demonstrates good pharmacokinetic activity in vivo.
news Main COVID-19 protease revealed, enabling screening of potential drugs 14 April 2020 | By Victoria Rees (Drug Target Review) Chinese researchers who determined the crystal structure of the COVID-19 protease Mpro used this information to screen over 10,000 compounds to combat the coronavirus.
news Possible novel cognitive anti-ageing targets identified 27 February 2020 | By Hannah Balfour (Drug Target Review) Researchers have shown that two epigenetic regulators could be targeted to improve cognitive and behavioural decline in age-related diseases like Alzheimer’s.
news Circular RNAs can regulate PKR activation in innate immunity 2 May 2019 | By Drug Target Review A recent study has discovered that covalently closed circular RNAs (circRNAs) preferentially bind to PKR which is related to innate immunity and act as PKR inhibitors.
