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Case Western Reserve University School of Medicine

Could downregulating the Drp1 protein prevent Alzheimer’s progression?

4 February 2021 | By Hannah Balfour (Drug Target Review)

In this article, we explore the findings of a study that suggests a newly identified pathway, the Drp1-HK1-NLRP3 signalling axis, could be a promising target for therapies to prevent Alzheimer’s disease progression.

neurons in purple surrounded by yellow protein aggregates - idea of Alzheimer's disease

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Researchers identify a novel tau aggregation control mechanism

2 December 2020 | By Hannah Balfour (Drug Target Review)

According to researchers, the more small tau protein variants expressed by neurons, the slower neurofibrillary tangles form.

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Researchers find mutation in CUL3 gene responsible for autism

26 November 2019 | By Victoria Rees (Drug Target Review)

Scientists have shown that the mutated CUL3 gene, which is involved in the cell’s clearance of proteins, plays a role in the development of autism and schizophrenia in mice.

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Five newest developments for imaging in drug research

12 August 2019 | By Victoria Rees (Drug Target Review)

Imaging methods are used by scientists to identify therapeutic targets and improve drug efficacy. This article lists five of the latest developments for imaging techniques.

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New therapy discovered to treat acute lymphoblastic leukaemia

30 July 2019 | By Drug Target Review

Researchers have discovered a new combination therapy to treat drug-resistant acute lymphoblastic leukaemia, tested in pre-clinical trials.

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Skin test detects prion infection before symptoms appear

23 January 2019 | By Iqra Farooq (Drug Target Review)

Researchers have developed a method of using skin samples to diagnose prion infections - even before they establish themselves...

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Depleting ErbB4 gene alleviates Schizophrenia symptoms in new mouse models

3 December 2018 | By Dr Zara Kassam (Drug Target Review)

Restoring brain cell receptors helps restore normal behaviour...

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Image of serotonin activating its receptor for the first time

2 November 2018 | By Drug Target Review

Researchers have managed to image serotonin activating its receptor for the first time using the cutting edge technology, cryo-electron microscopy...

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Drug target identified in oestrogen receptors

12 October 2018 | By Iqra Farooq (Drug Target Review)

A bridge-like structure in oestrogen has been identified by researchers at Case Western Reserve University School of Medicine as a potential drug target...

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New technique generates brain stem cells more efficiently

2 October 2018 | By Drug Target Review

Scientists in Ohio have developed a more efficient means of creating brain stem cells, specifically oligodendrocyte progenitor cells, or OPCs, which will help facilitate greater understanding of neurological disorders that result from myelin damage.

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Controlling immune cell migration as therapy for heart disease

7 May 2018 | By Drug Target Review

Researchers in the United States find that the location of the body’s immune cells correlates precisely with their function related to heart disease.

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RT-QuIC testing detects prion protein in the skin of CJD patients

23 November 2017 | By Dr Zara Kassam (Drug Target Review)

Scientists have detected abnormal prion protein in the skin of patients that have died from Creutzfeldt-Jakob disease...

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Case Western Reserve University School of Medicine