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Boston Children's Hospital

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Structural changes in SARS-CoV-2 Alpha and Beta variants revealed

28 June 2021 | By Victoria Rees (Drug Target Review)

A study has uncovered previously unknown properties of the Spike protein from the SARS-CoV-2 Alpha and Beta variants.

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Spike protein analysis explains faster spread of SARS-CoV-2 variants

18 March 2021 | By Victoria Rees (Drug Target Review)

Using cryo-electron microscopy, researchers have imaged how the SARS-CoV-2 Spike protein changes with the D614G mutation to enable faster spread of infection.

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Novel antibody-drug candidate to treat pancreatic cancer developed

10 November 2020 | By Victoria Rees (Drug Target Review)

Scientists have developed a new antibody-drug conjugate (ADC), made from ICAM1, an antibody that targets pancreatic cancer and the cytotoxic drug DM1 (mertansine).

COVID-19 coronavirus particles in grey surrounding red lungs on a black background

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COVID-19 research indicates SARS-CoV-2 exploits immune defences to drive infection

22 April 2020 | By Hannah Balfour (Drug Target Review)

A new study has revealed that less than 10 percent of respiratory and intestinal cells are susceptible to SARS-CoV-2 infection and expression of ACE2 receptors is driven by the body's immune response.

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Using CRISPR-Cas9 to identify new gene drug targets

26 March 2020 | By Victoria Rees (Drug Target Review)

Researchers have used CRISPR-Cas9 to screen the genome for possible targets that could be used in potential treatments for muscular dystrophy.

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Method to coax immune system into selecting HIV antibodies developed

9 December 2019 | By Hannah Balfour (Drug Target Review)

Immunogens can be used to coax the immune system into producing broadly neutralising antibodies to fight a HIV infection, making a vaccine against the condition more likely, say researchers.

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Antibodies used to treat and reverse MS symptoms in mice

7 October 2019 | By Victoria Rees (Drug Target Review)

Researchers have identified a protein on the surface of cells that cause MS and have used antibodies as an effective treatment for the condition in mice.

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Breast cancer progression may be halted with CRISPR gene editing

26 August 2019 | By Rachael Harper (Drug Target Review)

A tumour-targeted CRISPR gene editing system encapsulated in a nanogel could halt the growth of triple-negative breast cancer.

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Four cell types discovered in glioblastoma tumours

12 August 2019 | By Victoria Rees (Drug Target Review)

A new study has revealed that glioblastomas contain four different types of cell which the researchers say should be treated separately.

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New research advances the possibility of regenerating tissue after a heart attack

23 April 2019 | By Drug Target Review

This research advances the possibility of reviving the heart's regenerative capacities using microRNAs.

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Pre-clinical testing with in vitro model may streamline vaccine development

20 November 2018 | By Drug Target Review

A team of scientists have developed the first modelling system for testing age-specific human immune responses to vaccines -- outside the body...

news

Early treatment could reverse autistic behaviour in tuberous sclerosis

10 October 2018 | By Drug Target Review

Scientists may have found a sensitive time period where autism related social deficits could be reversed in tuberous sclerosis...

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Transparent high-resolution EEG array allows brain imaging

7 September 2018 | By Drug Target Review

Researchers have developed a see-through, dual-layered, mesh EEG device which is capable of measuring the electrical activity of individual neurons...

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Scientists reverse diabetes using modified blood stem cells

16 November 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have successfully reversed type 1 diabetes by infusing blood stem cells pre-treated to produce more PD-L1...

news

New study links neuropilin 2 deficiency to inflammation-induced edema & lymphedema

14 October 2016 | By Niamh Louise Marriott, Digital Content Producer

The Nrp2 knockout mice showed massively increased and prolonged edema following inflammation. Investigation into this finding led Bielenberg's laboratory...

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Boston Children's Hospital