news Novel technology could significantly advance genomics field 16 September 2021 | By Anna Begley (Drug Target Review) New technology system of drug-based markers for the selection or counter-selection of genes may advance genetic screening methods.
news New screening method identifies COVID-19 protein inhibitor 3 September 2021 | By Anna Begley (Drug Target Review) Researchers use fast and cost-effective technology to identify the viral protein inhibitor Mpro as a potential drug against COVID-19.
news Novel model developed to resemble aberrant IPF lung epithelium 31 August 2021 | By Anna Begley (Drug Target Review) A new model that closely resembles aged lung epithelium in idiopathic pulmonary fibrosis has been developed, possibly leading to treatments.
news NPSR1 gene discovered as a key cause of endometriosis 31 August 2021 | By Anna Begley (Drug Target Review) NPSR1 has been identified as a genetic cause of endometriosis, revealing a potential drug target that may lead to better therapies.
news Novel gene therapy for heart failure moves closer to clinic 6 July 2021 | By Anna Begley (Drug Target Review) New research by US institutions in pigs shows that knocking down a particular signalling pathway after heart failure renews heart tissue.
news Reference genome comparison finds exome variant discrepancies 15 June 2021 | By Victoria Rees (Drug Target Review) Scientists have found differences in 206 genes between the GRCh38 (hg38) and GRCh37 (hg19) human reference genomes.
news Analysis of proteomic data reveals potential therapeutic targets for cancer 8 March 2021 | By Victoria Rees (Drug Target Review) Researches have provided a proof-of-concept that proteomic analysis could be used to identify drivers of aggressive cancers.
news Researchers find MAPK4 enzyme presents target for prostate cancer 22 February 2021 | By Victoria Rees (Drug Target Review) Research has shown that MAPK4 activates two molecules in cellular signalling pathways involved in prostate cancer growth.
news ES17 phages can destroy bacteria before gut infection in mice 10 February 2021 | By Victoria Rees (Drug Target Review) A study has shown that the ES17 phage binds to heparan sulphate and can target and eliminate ExPEC bacteria in animal models.
news Drug target for spinocerebellar ataxia type 1 identified by researchers 10 August 2020 | By Victoria Rees (Drug Target Review) A team has found that a mutation in the ATAXIN-1 gene causes spinocerebellar ataxia type 1 (SCA1), presenting a drug target for the condition.
news Key regulator of sperm maturation revealed as a target for male infertility treatments 13 July 2020 | By Hannah Balfour (Drug Target Review) Scientists demonstrated that NELL2, a factor release by the testis, is essential for sperm to mature into motile cells able to fertilise an egg.
article Using scientific literature to aid the development of a safe and effective COVID-19 vaccine 2 June 2020 | By Victoria Rees (Drug Target Review) Researchers in the US describe how they utilised previously published scientific literature to guide the design of their potential COVID-19 vaccine.
news VP3 protein: revealing the structure of a potential rotavirus drug target 17 April 2020 | By Hannah Balfour (Drug Target Review) Researchers hope that by revealing the rotavirus VP3 protein structure and mRNA capping functions, novel antivirals could be designed to prevent or combat rotavirus infections.
news Alternative splicing regulators like AKAP8 prevent cancer metastasis 28 January 2020 | By Hannah Balfour (Drug Target Review) A study revealed that AKAP8 promotes the alternative splicing of proteins, preventing breast cancer metastasis in animal models and could be the target of future therapies.
news Antiviral treatments lead to development of a new kind of cancer drug 24 January 2020 | By Rachael Harper (Drug Target Review) Drugs that were being developed to treat enterovirus have also been found to treat certain cancers in mice.
