Faster drug discovery could hit ‘undruggable’ targets
A new technique has been developed which has the potential to harness bacteria to produce billions of different drug candidates to treat diseases like cancer.
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Computer model mapping protein interactions could cut pre-drug screening time
Modelling technique that simultaneously evaluates the effects of possible protein mutations on protein-protein interactions implicated in disease, could cut pre-drug screening time, says research.
Could Frizzled receptors be the target of new cancer therapeutics?
The G-protein coupled receptor Frizzled, implicated in diseases like cancer, can be targeted with small molecules which could provide the basis for anti-cancer therapeutics, according to researchers.
Pharmacological chaperone therapy shown to prevent Alzheimer’s in mice
A new study is the first to describe a novel pharmacological chaperone that is capable of preventing Alzheimer's disease in mice.
Antiviral compound could be used to fight influenza
A study in mice has found that a compound modelled on a protein found in bananas safely protects against multiple strains of the influenza virus.
Combination therapy of α -KLOTHO and TGFβR2 improves osteoarthritis
A study has shown that a combination of α-KLOTHO and TGF β receptor 2 (TGFβR2) recovers cartilage in rats with osteoarthritis and could be a new therapy for humans.
Researchers develop technique to map protein-drug interactions
A new method of melting proteins has allowed researchers to identify new potential drug targets by revealing protein-drug interactions.
New T-cell therapy could provide universal cancer treatment
Researchers have discovered a new type of T-cell receptor that can kill most cancer types while leaving healthy cells unharmed.
Researchers discover how gut infections may produce chronic symptoms
A new study into why neurons in the gut die and how the immune system protects them could lead to better treatments for IBS that work by boosting polyamine production.
Dozens of anti-cancer compounds revealed by screening existing drugs
Researchers have screened thousands of existing drug molecules against cancer cell lines to discover almost 50 compounds that combat the condition.
Researchers use CRISPR to identify proteins that prevent inflammation
New findings using CRISPR have shown that the IL-4 and IL-13 proteins can protect the body against inflammation from autoimmune diseases.
Cell division recreated in a test tube demonstrates TPX2 protein role in cancer
Studies have identified that the TPX2 protein recruits the molecular machinery required for the branching microtubule nucleation process, so could be a target for cancer therapies.
Levels of neurogenesis could be a therapeutic target in neurodegenerative disease
Research has identified that regions of the brain can regenerate via neural stem cells and the process of neurogenesis which could provide a new avenue for regenerative therapeutics.
PCSK6 enzyme plays a key role in vascular disease, according to research
A new study has demonstrated that the enzyme proprotein convert subtilisin/kexin 6 causes structural and functional remodelling in vascular disease, so could be a new therapeutic target.
Mutations in non-coding regions of the cancer genome could drive tumour growth
Research into the role of non-coding DNA in cancer development and progression has identified 30 regions that may contribute to tumour growth, which could be therapeutic targets.
