Investigational drug kills pancreatic cells in mice by cutting off cysteine supply 3 April 2020 | By Victoria Rees (Drug Target Review) Researchers have demonstrated that cysteinase, a new drug compound, can starve pancreatic cells of cysteine supply, causing ferroptosis.
Two compounds identified as circadian clock modulators 3 April 2020 | By Victoria Rees (Drug Target Review) Researchers have developed two small molecules which target two components of the circadian rhythm and could be used to lengthen the body clock.
Organoids for the development of drugs and diagnostics for NASH 3 April 2020 | By Hannah Balfour (Drug Target Review) Organoids at different stages of non-alcoholic steatohepatitis (NASH) progression have been created to help in drug design and identification of diagnostic biomarkers.
Novel COVID-19 vaccine shows efficacy in mice 3 April 2020 | By Victoria Rees (Drug Target Review) Researchers have developed a vaccine against the COVID-19 coronavirus which induced the rapid production of antibodies in mice.
Decoy ACE2 receptors could be promising COVID-19 infection-preventing drug 3 April 2020 | By Hannah Balfour (Drug Target Review) Recombinant angiotensin converting enzymes (ACE2) reduced infection and viral growth in cell cultures and organoids by acting as a decoy for SARS-CoV-2.
Experimental mouse model of Duchenne muscular dystrophy developed 2 April 2020 | By Victoria Rees (Drug Target Review) Researchers have created an accurate mouse model of Duchenne muscular dystrophy (DMD), showing that TGFβ is a potential target for the condition.
Biotech and academia collaborate on intranasal COVID-19 vaccine development 2 April 2020 | By Hannah Balfour (Drug Target Review) The University of Alabama at Birmingham (UAB) will run the pre-clinical trials of Altimmune’s intranasal COVID-19 vaccine candidate, AdCOVID.
Researchers develop CAR-T therapy that targets multiple leukaemia sites 2 April 2020 | By Victoria Rees (Drug Target Review) A new CAR T-cell therapy has been created by researchers which targets three proteins on leukaemia cells and has shown success in pre-clinical trials.
ABCC4 transporter could be a novel target for paediatric medulloblastoma treatments 2 April 2020 | By Hannah Balfour (Drug Target Review) Researchers demonstrated that ABCC4 is essential to signalling in the SHH subgroup of medulloblastomas and when expression was reduced in mice, the tumours shrank.
AI technology to screen existing drugs for use against COVID-19 2 April 2020 | By Victoria Rees (Drug Target Review) A collaboration aims to utilise a compound library of 15,000 clinically-ready molecules and screen then against three COVID-19 targets.
COVID-19 update: funding for treatments and vaccines 1 April 2020 | By Victoria Rees (Drug Target Review) Drug Target Review rounds up the latest announcements regarding funding for research into COVID-19 treatments and vaccines.
Novel CAR T-cell immunotherapy eradicates solid tumours in mice 1 April 2020 | By Victoria Rees (Drug Target Review) Researchers have developed a new CAR T-cell therapy that targets an antigen called glycipan-1 (GPC1), showing efficacy at fighting solid tumours in mice.
Novel tuberculosis transport protein could be target of new treatments 1 April 2020 | By Hannah Balfour (Drug Target Review) Cryogenic electron microscopy revealed that the vitamin B12 transporter on Mycobacterium tuberculosis acts like a non-selective sluice, transporting both the vitamin and antibiotics.
Scientists reveal structure of norovirus using cryo-EM 1 April 2020 | By Victoria Rees (Drug Target Review) Researchers captured 13,000 images of a mouse norovirus using an electron microscope and compiled the images to reveal the structure of the virus.
Free access to AI Clinical Research Navigator tool for COVID-19 researchers 1 April 2020 | By Hannah Balfour (Drug Target Review) In light of the COVID-19 pandemic, the creators of the Clinical Research Navigator (CRN) tool have offered free access to their system for biomedical researchers.
