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Researchers identify over 550 cancer-driving genes

20 August 2020 | By Victoria Rees (Drug Target Review)

Computational analysis has been used by researchers to examine 66 types of cancer and identify 568 genes that drive tumour development.

hand holding petri dish in which antibiotic sensitivity has been tested with bacteria, leaving rings surrounding paper disks containing compounds

Researchers discover a novel class of antibiotics for urinary tract infections

19 August 2020 | By Hannah Balfour (Drug Target Review)

Researchers reveal their antibiotics disrupt the bacterial TonB system which uropathogenic E. coli (UPEC) uses to uptake iron in order to cause urinary tract infections.

A microscopy image of neuromuscular junctions with projections from the neurons (grey/black) connecting to the muscles (purple).

Age-related decline in motor function could be prevented using gene therapy

19 August 2020 | By Hannah Balfour (Drug Target Review)

Enhancing neuromuscular junction (NMJ) formation using DOK7 gene therapy improved muscle strength and motor function in aging mice.

Drug candidate outperforms remdesivir as COVID-19 antiviral in cell assays

18 August 2020 | By Victoria Rees (Drug Target Review)

A compound called BOLD-100, which has shown efficacy against COVID-19 in pre-clinical trials, has now outperformed remdesivir in a cytopathic effect assay.

Method to synthetically produce terpenes developed by researchers

18 August 2020 | By Victoria Rees (Drug Target Review)

Scientists have developed a synthetic biology process using enzymes to create three families of terpenes, potential starting points for new drugs.

Researchers observe interaction between antibodies and target proteins

17 August 2020 | By Victoria Rees (Drug Target Review)

Using cryogenic electron microscopy, scientists have observed the interaction between antibodies and their target molecules, providing information that could be utilised in the development of synthetic antibodies.

COVID-19 vaccine elicits high levels of neutralising antibodies in mice

17 August 2020 | By Victoria Rees (Drug Target Review)

A potential COVID-19 vaccine, made from a modified vesicular stomatitis virus with the SARS-CoV-2 Spike protein, was shown to protect mice against the virus.

Researchers treat diffuse intrinsic pontine glioma in mice

17 August 2020 | By Victoria Rees (Drug Target Review)

Researchers have treated diffuse intrinsic pontine glioma (DIPG), a fatal childhood brain cancer, in mice by targeting two metabolic pathways.

Researchers identify protein that may help SARS-CoV-2 spread through cells

14 August 2020 | By Victoria Rees (Drug Target Review)

Researchers have found that the SARS-CoV-2 nucleocapsid protein may help the virus to spread from cell to cell, providing a drug target.

Gastric wound - need for bioprinting to treat wound

Potential in situ and in vivo bioprinting method developed by researchers

14 August 2020 | By Victoria Rees (Drug Target Review)

Researchers have developed a way for a microrobot to bioprint new cells directly onto gastric wounds inside the body, which they tested in cells.

Machine learning reveals potential COVID-19 therapeutic compounds

13 August 2020 | By Victoria Rees (Drug Target Review)

A drug screen using machine learning has identified hundreds of potential drugs that could be used to treat COVID-19, researchers say.

Metastasis-preventing drug target for pancreatic cancer identified

13 August 2020 | By Victoria Rees (Drug Target Review)

A protein called PPP1R1B has been revealed as a drug target for pancreatic cancer as it stopped the metastasis of tumours in mice.

Novel molecule effectively treats arthritis in mice, study shows

12 August 2020 | By Victoria Rees (Drug Target Review)

A molecule called TPPU has been shown to inhibit an enzyme that plays a key role in inflammation, successfully treating arthritis in mice.

Potential COVID-19 treatment and vaccine combination shows success in cells

12 August 2020 | By Victoria Rees (Drug Target Review)

A possible treatment and vaccine combination for COVID-19 has shown positive results in pre-clinical studies using human cells.

Stem cells differentiated into heart cells

3D printing technique differentiates stem cells into heart cells

12 August 2020 | By Victoria Rees (Drug Target Review)

A new study has shown that 3D printing can be used to control stem cell differentiation into embryoid bodies that replicate heart cells.

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