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elderly woman holding hand of young doctor

Age may be a primary determinant of melanoma treatment resistance

4 November 2020 | By Hannah Balfour (Drug Target Review)

Scientists have shown that age may cause genetically identical melanoma skin cancer cells to respond differently to treatment, making age a primary factor in treatment response.

Macrophage (white spiky blob) in front of red tissue

Exosome-educated macrophages show potential to treat ligament injuries

4 November 2020 | By Hannah Balfour (Drug Target Review)

In a new rodent study, researchers show how delivering exosome-educated macrophages (EEMs) can accelerate the repair of ligament damage, while simultaneously reducing inflammation and scarring.

Researchers use somatostatin to treat Alzheimer’s in mice

4 November 2020 | By Victoria Rees (Drug Target Review)

A team fused the peptide somatostatin to a brain transport protein and found it treated memory loss associated with Alzheimer's in mice.

Brain lit up in blue on a circuit board - idea of machine learning/artificial intelligence

Using machine learning to guide and enhance bioengineering

3 November 2020 | By Hannah Balfour (Drug Target Review)

The Automated Recommendation Tool (ART) uses machine learning to accelerate the development of cells for specified goals, eg, bioprocessing and bioproduction.

cartoon of a blood vessel with coronavirus particles attached to the lining of the vessel and a blood clot formed of red and white blood cells

Autoantibodies and over-active neutrophils may be cause of COVID-19 blood clots

3 November 2020 | By Hannah Balfour (Drug Target Review)

According to a new study, blood clots in patients with severe COVID-19 are caused by an autoimmune antibody that circulates in the blood and attacks cells.

woman scratching the back of her leg while walking on grass - idea of allergic reaction itching

Researchers reveal how allergens may trigger itching

2 November 2020 | By Hannah Balfour (Drug Target Review)

Certain sensory neurons and Substance P are potential drug targets for the development of novel allergy preventions or treatments, according to scientists.

shape of a human brain constructed out of red coronavirus particles

SARS-CoV-2 can disrupt the blood-brain barrier, find scientists

2 November 2020 | By Hannah Balfour (Drug Target Review)

Binding of SARS-CoV-2 spike proteins to the brain’s endothelial cells can cause the blood-brain barrier to become leaky, potentially causing the neurological symptoms associated with COVID-19.

Golden DNA strand disintegrating on a black background

CRISPR editing can result in whole chromosome elimination, say scientists

2 November 2020 | By Hannah Balfour (Drug Target Review)

In a new study, scientists identify some of the pitfalls when using CRISPR Cas9 to correct mutations in human embryos, such as the destruction of whole chromosomes.

red immune cell attacking a blue cancer cell on a dark blue background

Researchers develop novel class of cancer immunotherapy

30 October 2020 | By Hannah Balfour (Drug Target Review)

The scientists developed a therapy which uses nanobiologics to train the innate immune system to recognise and combat cancer cells.

blue viral particles surrounded by blue antibodies on a red gradient background

SARS-CoV-2 specific antibodies persist for five months in mild cases

30 October 2020 | By Hannah Balfour (Drug Target Review)

In a study of mild-to-moderate COVID-19 patients scientists established that the level of certain antibodies remained stable for five months.

Researchers discover novel cancer immunosuppression mechanism

30 October 2020 | By Hannah Balfour (Drug Target Review)

According to the study, the transcription factor IRF4 drives T cell differentiation and immunosuppression in multiple human cancers.

SARS-CoV-2 particles infecting a human cell

Lysosomes key to coronavirus shedding, finds study

29 October 2020 | By Hannah Balfour (Drug Target Review)

Scientists reveal that coronaviruses de-activate lysosomes before using them to exit infected cells and spread through the body.

Leveraging flow cytometry to explore COVID-19 immune responses

29 October 2020 | By Hannah Balfour (Drug Target Review)

Researchers used flow cytometry to characterise which types of T cells are involved in the immune response to COVID-19 and what they target.

Scientists identify new way to target leukaemia cells

28 October 2020 | By Victoria Rees (Drug Target Review)

Researchers have found they can make leukaemia cells vulnerable by dislodging leukaemia stem cells from a tumour-promoting niche.

heart on an abstract blue scientific background

Organs-on-a-chip model for breast cancer drug cardiac toxicity testing

27 October 2020 | By Hannah Balfour (Drug Target Review)

The newly developed chip includes heart and breast cancer tissues and could be used to predict the cardiac toxicity of chemotherapeutic drugs.

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