‘Neuroregenerative’ study uses glial cells for stroke repair in primates 16 November 2020 | By Victoria Rees (Drug Target Review) In rhesus macaques, a team were able to induce neural regeneration from brain internal glial cells, repairing damage from stroke.
Researchers suggest SKI complex of SARS-CoV-2 as novel drug target 16 November 2020 | By Victoria Rees (Drug Target Review) Researchers have discovered new drug compounds that target the SKI complex of SARS-CoV-2, preventing replication.
New 3D cell culture method could enable personalised cancer therapies 13 November 2020 | By Victoria Rees (Drug Target Review) A team has extracted single tumour cells from existing cell lines to create 3D cell cultures that could allow for personalised cancer therapies.
Scientists unveil virtual reality tool for COVID-19 drug development 13 November 2020 | By Hannah Balfour (Drug Target Review) The tool uses interactive molecular dynamics simulations in virtual reality (iMD-VR) to allow researchers to step inside SARS-CoV-2 enzymes and visualise molecules binding to them.
Researchers dicover novel targets for rheumatoid arthritis therapies 13 November 2020 | By Hannah Balfour (Drug Target Review) Researchers have identified that autoreactive B cells and a protein that enables them to invade joints could be promising drug targets for the most common inflammatory arthritis.
Researchers reveal structure of SARS-CoV-2 Envelope protein 13 November 2020 | By Victoria Rees (Drug Target Review) The molecular structure of the SARS-CoV-2 Envelope protein has been identified by researchers using nuclear magnetic resonance.
Furin cleavage motif makes SARS-CoV-2 more aggressive than other CoVs, find scientists 12 November 2020 | By Hannah Balfour (Drug Target Review) A specific furin cleavage motif on the SARS-CoV-2 Spike protein, not present on other coronaviruses (CoVs), could be targeted by novel COVID-19 therapies.
Anti-C5aR antibody shows promise as immuno-oncology treatment 12 November 2020 | By Victoria Rees (Drug Target Review) Pre-clinical studies have shown that the TJ210/MOR210 monoclonal antibody is successful at targeting tumours.
Cell line development services market to grow at 13.3 percent 12 November 2020 | By Hannah Balfour (Drug Target Review) Reports suggest the market growth is driven by advances in biotechnology and its applications, as well as COVID-19 research.
Study suggests beta cell regeneration driven by circadian rhythms 12 November 2020 | By Victoria Rees (Drug Target Review) Researchers have shown that the internal clock controls the regenerative mechanism behind beta cells in diabetic mice.
Editing CHO cells with CRISPR-Cas9 improves cell growth and reduces by-products 11 November 2020 | By Victoria Rees (Drug Target Review) Researchers have found bioengineering CHO cells using CRISPR-Cas9 can decrease the secretion of metabolic by-products that hinder growth.
Researchers accelerate organoid development and selection using algorithm 11 November 2020 | By Hannah Balfour (Drug Target Review) The semi-automated process enabled researchers to make retinal organoid production and selection nearly four times faster.
Novel nanoparticle therapy shows promise in glioblastoma 11 November 2020 | By Hannah Balfour (Drug Target Review) The synthetic protein nanoparticle can cross the blood-brain barrier and deliver a targeted therapeutic to glioblastoma cells, say researchers.
RNA structures of SARS-CoV-2 reveal potential drug targets 11 November 2020 | By Victoria Rees (Drug Target Review) The SARS-CoV-2 RNA genome structure has been studied by researchers who identified several potential drug targets.
New bioprocess generates haematopoietic stem and progenitor cells 10 November 2020 | By Victoria Rees (Drug Target Review) A new single-use, closed-system upstream bioprocess has been developed which enables the production of large number of haematopoietic stem cells and progenitor cells.
![robotic hand pipetting from petri dish of organoids next to a clock - idea of automation speeding up organoid development [Credit: Daria Sokol/MIPT Press Office].](https://drug.russellpublishing.co.uk/wp-content/uploads/algorithm-accelerating-organoid-development.jpg)
