Synthetic llama antibodies used to rescue mutated proteins 8 December 2020 | By Victoria Rees (Drug Target Review) Engineered deubiquitinases combines a synthetic nanobody that recognises a protein that can rescue proteins tagged for destruction.
Proteomics study to investigate plasma proteins in 53,000 participants 8 December 2020 | By Victoria Rees (Drug Target Review) Next-generation sequencing will be employed to study 1,500 plasma proteins in participants, according to UK Biobank.
Novel target for pulmonary fibrosis identified using tissue from COVID-19 patients 7 December 2020 | By Hannah Balfour (Drug Target Review) Study suggests reducing the expression of the methyl-CpG-binding domain 2 (MBD2) protein on macrophages could be a viable therapeutic strategy for lung fibrosis.
New embryonic stem cell type could advance regenerative medicine 7 December 2020 | By Hannah Balfour (Drug Target Review) Scientists suggest that research using XPSCs, an intermediate form of embryonic stem cell, could help accelerate the development of stem cell-derived tissues and organs for transplantation.
Oral drug blocks SARS-CoV-2 transmission in ferrets, researchers find 4 December 2020 | By Victoria Rees (Drug Target Review) A team has found that their drug Molnupiravir (MK-4482/EIDD-2801) acts as an antiviral against SARS-CoV-2 in pre-clinical studies.
Microscopy reveals four classes of SARS-CoV-2 neutralising antibodies 4 December 2020 | By Hannah Balfour (Drug Target Review) Researchers show that neutralising antibodies targeting the SARS-CoV-2 Spike protein have four distinct structures.
New insulin molecule can self-regulate blood sugar in rats 4 December 2020 | By Victoria Rees (Drug Target Review) Researchers have developed a novel insulin molecule that responds to glucose levels in the blood sugar of rats, which they say could help patients with type 1 diabetes.
A novel CAR T-cell therapy for type 1 diabetes 4 December 2020 | By Hannah Balfour (Drug Target Review) Researchers show how genetically engineered five-module chimeric antigen receptor (5MCAR) T cells can be directed to destroy T cells causing autoimmune diseases.
Researchers provide new insights into SARS-CoV-2 lung pathology 3 December 2020 | By Hannah Balfour (Drug Target Review) The new study shows how SARS-CoV-2 significantly remodels cellular processes in just an hour and identifies potential drug targets and therapeutics for COVID-19.
CRISPR tagging used to grow neuronal cells from stem cells 3 December 2020 | By Victoria Rees (Drug Target Review) A new technique using CRISPR has been developed by researchers to identify programmed stem cells that mature into neuronal cells.
Novel peptide therapy improves COVID-19 survival by LEAPS and bounds in mice 3 December 2020 | By Hannah Balfour (Drug Target Review) Researchers report that their LEAPS COV-19 peptides significantly improved survival in a murine model of COVID-19.
Mitochondrial protein revealed as target for cardiovascular disease 3 December 2020 | By Victoria Rees (Drug Target Review) According to new research, the protein ALDH4A1 is a possible therapeutic target and diagnostic biomarker for cardiovascular disease.
New virus-like probes could make COVID-19 tests more accurate and reliable 2 December 2020 | By Hannah Balfour (Drug Target Review) The novel probes, known as positive controls, could make it easier to validate rapid, point-of-care diagnostic tests for COVID-19 across the globe.
Researchers identify a novel tau aggregation control mechanism 2 December 2020 | By Hannah Balfour (Drug Target Review) According to researchers, the more small tau protein variants expressed by neurons, the slower neurofibrillary tangles form.
Drug target to tackle COVID-19 inflammatory processes identified 2 December 2020 | By Victoria Rees (Drug Target Review) Researchers have shown that the presence of the inflammasome mediated by NLRP3 is a marker and drug target for COVID-19-related cytokine storms.
