Researchers develop computer algorithm to identify cancer cell lines 14 December 2020 | By Victoria Rees (Drug Target Review) Scientists have trained a computer algorithm to identify differences in cancer cell lines based on microscopic images, preventing the misclassification of cells.
Protein identified as potential target for leishmaniasis vaccines 14 December 2020 | By Victoria Rees (Drug Target Review) New research has demonstrated in mouse models that the SHP-1 protein limits the capacity of dendritic cells, making it a target for a leishmaniasis vaccine.
Computational mass spectrometry method accelerates speed of data acquisition 11 December 2020 | By Victoria Rees (Drug Target Review) A new subspace mass spectrometry imaging method has enabled researchers to provide data sets exponentially faster.
Haematoxylin could be a promising therapy for bone marrow cancers 11 December 2020 | By Hannah Balfour (Drug Target Review) Study shows that haematoxylin can selectively kill cancers with a mutated form of the calreticulin gene (CALR), common in a group of bone marrow cancers called myeloproliferative neoplasms (MPNs).
Inhaled vaccine induces strong immune response in animal models 11 December 2020 | By Hannah Balfour (Drug Target Review) Scientists report their phage-based inhaled vaccine delivery system elicited a robust antibody response in both mice and non-human primates.
Brain organoids used to identify promising treatments for Rett syndrome 10 December 2020 | By Hannah Balfour (Drug Target Review) Two drugs, Nefiracetam and PHA 543613, were able to return neuronal signalling to near normal in organoids derived from patients with the autism spectrum disorder, Rett syndrome.
Studies in mice reveal link between obesity and tumour growth 10 December 2020 | By Victoria Rees (Drug Target Review) New research has provided a metabolic atlas for insights into obesity and tumours' ability to hide from the immune system.
Novel target could treat both SARS-CoV-2 and other coronaviruses 10 December 2020 | By Hannah Balfour (Drug Target Review) Scientists shows targeting cholesterol or phosphatidylinositol phosphate (PIP) could be a promising strategy to combat multiple coronaviruses.
Non-hallucinogenic version of ibogaine could treat addiction and depression 10 December 2020 | By Victoria Rees (Drug Target Review) A non-hallucinogenic version of the psychedelic drug ibogaine could treat psychiatric disorders, pre-clinical trials have shown.
Biomarker for blood vessel damage found in children with SARS-CoV-2 9 December 2020 | By Victoria Rees (Drug Target Review) Elevated levels of a biomarker related to blood vessel damage have been found in all children with SARS-CoV-2 infection.
Mitochondrial replacement therapy (MRT) shown to be safe in monkeys 9 December 2020 | By Hannah Balfour (Drug Target Review) A long-term study of macaques given mitochondrial replacement therapy (MRT) found that both treated individuals and their offspring were healthy and developed normally.
Role of gene in metastasis of brain cancer revealed 9 December 2020 | By Victoria Rees (Drug Target Review) Researchers have shown how increased YTHDF3 expression correlates with brain cancer metastases, making it a target for the condition.
Inhibiting cadherin 11 significantly increases survival of mice with pancreatic cancer 9 December 2020 | By Hannah Balfour (Drug Target Review) Mice treated with a small molecule inhibitor of cadherin 11 (CDH11) had reduced pancreatic cancer growth and increased survival time.
Red propolis could be a better treatment for schistosomiasis 8 December 2020 | By Hannah Balfour (Drug Target Review) Investigators found that red propolis can kill schistosomes at all stages of development and therefore suggest it could be highly effective for treating schistosomiasis.
Triggering an IgA response could increase COVID-19 vaccine efficacy 8 December 2020 | By Hannah Balfour (Drug Target Review) Two new studies suggest that SARS-CoV-2-specific IgA antibodies are more neutralising and therefore COVID-19 vaccines should encourage an IgA response.
