New DNA-editing technique extends lifespan of mice with progeria 7 January 2021 | By Victoria Rees (Drug Target Review) Researchers have used a novel DNA-editing method to convert one base pair to another, increasing the lifespan of mice with progeria.
Immunotherapy with radiotherapy could improve outcomes of cancers in liver 6 January 2021 | By Victoria Rees (Drug Target Review) Researchers have discovered that in mice with cancers in the liver, immunotherapy and radiotherapy prevented T-cell death.
New drug target for non-small cell lung cancer identified 6 January 2021 | By Victoria Rees (Drug Target Review) A new study has suggested that the enzyme GFPT2 could be a useful target for non-small cell lung cancer (NSCLC).
NIK could be key to enhancing the effects of immunotherapy 6 January 2021 | By Hannah Balfour (Drug Target Review) Immunology study shows that NF-kappa B-inducing kinase (NIK) is critical to T cell metabolism and the antitumour immune response.
Macaques and baboons show success as models to study SARS-CoV-2 6 January 2021 | By Victoria Rees (Drug Target Review) Researchers have shown rhesus macaques and baboons develop strong signs of acute viral infection from SARS-CoV-2, making them ideal models.
Novel prostate cancer resistance mechanism could be a promising target 6 January 2021 | By Hannah Balfour (Drug Target Review) By inhibiting the activity of microRNA-194 (miR-194), scientists prevented prostate cancer cells from developing treatment resistance in vitro.
Potential probiotic treatment identified for type 2 diabetes 5 January 2021 | By Victoria Rees (Drug Target Review) Researchers have identified microbes that could affect the way a person metabolises glucose and lipids, leading to a potential treatment for type 2 diabetes.
Brain injury may drive the development of cancer 5 January 2021 | By Hannah Balfour (Drug Target Review) A new study reveals that the healing process following a brain injury could initiate the growth of glioblastoma cancers.
Novel bronchodilator could be used for control of asthma 5 January 2021 | By Hannah Balfour (Drug Target Review) Study identifies a promising new compound that can open constricted airways and could be a promising treatment for obstructive lung diseases.
Blood vessel damage likely causes neurological symptoms of COVID-19, finds study 4 January 2021 | By Hannah Balfour (Drug Target Review) A new study suggests that inflammation and blood vessel damage may be the primary causes of neurological symptoms in COVID-19 patients, instead of the virus infecting the brain.
Drug screening reveals pralatrexate could be repurposed to treat COVID-19 4 January 2021 | By Victoria Rees (Drug Target Review) Computational drug screening has shown that chemotherapy drug pralatrexate could potentially be repurposed to treat COVID-19.
Activating STING enhances CAR T-cell activity in solid tumours, shows study 4 January 2021 | By Hannah Balfour (Drug Target Review) Researchers were able to eradicate breast cancer in mice when they combined CAR T cells with STING pathway agonists and immunotherapeutic antibodies.
Researchers develop new potential stroke treatment 4 January 2021 | By Victoria Rees (Drug Target Review) A team has shown that synthetic molecule LAU-0901 plus aspirin-triggered NPD1 can repair brain damage in an experimental model of stroke.
Novel vaccine could counter dangerous effects of synthetic cannabinoids 28 December 2020 | By Victoria Rees (Drug Target Review) In pre-clinical trials, researchers have shown that a new vaccine could combat the dangerous effects of synthetic cannabinoids.
Potential therapeutic target identified for stomach cancer 22 December 2020 | By Victoria Rees (Drug Target Review) A team has shown that removing the inflammatory signalling protein TNF in a laboratory model prevented stomach cancers from becoming severe.
