Balanced T-cell response key to asymptomatic COVID-19, study suggests 2 March 2021 | By Victoria Rees (Drug Target Review) A new study has suggested that asymptomatic individuals with COVID-19 mount an efficient T-cell response that protects the host.
Atomic force microscopy used to study endonuclease digestion of DNA nanostructures 2 March 2021 | By Victoria Rees (Drug Target Review) A team of researchers have used microscopy techniques to monitor DNA degradation and anticancer drug release from nanostructures.
Screening by compound activity could accelerate drug discovery 2 March 2021 | By Victoria Rees (Drug Target Review) Researchers have developed a new screening technique called biological activity-based modelling to identify drug candidates.
Vaccine strategy developed to fight urinary tract infections 2 March 2021 | By Victoria Rees (Drug Target Review) Researchers have shown that administering a urinary tract infection vaccine directly to the bladders of mice helped them to effectively fight bacteria.
SARS-CoV-2 model shows Spike protein co-operation 1 March 2021 | By Victoria Rees (Drug Target Review) A new coarse-grained model of the complete SARS-CoV-2 virion has revealed potential new ways to combat the coronavirus.
New bioinformatics tool accurately tracks synthetic DNA 1 March 2021 | By Victoria Rees (Drug Target Review) A team has demonstrated that their bioinformatics approach, PlasmidHawk, can analyse DNA sequences to identify the source of engineered plasmids.
Hymecromone can suppress neuroinflammation in astrocytes, study shows 1 March 2021 | By Victoria Rees (Drug Target Review) Researchers have found that the spasmolytic drug hymecromone can suppress astrocyte inflammatory responses, meaning it could be used to combat Alzheimer's disease.
Computational method used to quantify tRNAs in any organism 1 March 2021 | By Victoria Rees (Drug Target Review) Researchers have developed a new technique called mim-tRNAseq to measure, map and analyse tRNAs in cells, providing insight into disease.
Scientists uncover structural biology details of SARS-CoV-2 infection 26 February 2021 | By Victoria Rees (Drug Target Review) Researchers have used computer simulations to model how the SARS-CoV-2 fusion peptide interacts with and penetrates the cell membrane.
Drugs with potential to stop plaque build-up in arteries identified 26 February 2021 | By Victoria Rees (Drug Target Review) A new compound can inhibit the build-up of plaque in arteries and prevent atherosclerosis, researchers have shown.
High-throughput screening market set to be worth $26.4bn by 2025 26 February 2021 | By Victoria Rees (Drug Target Review) According to a new report, the high-throughput screening market will increase at a CAGR of 11.5 percent from 2020 to 2025.
New fluorescence imaging method enables live RNA visualisation 26 February 2021 | By Victoria Rees (Drug Target Review) A fluorescence imaging technique has allowed scientists to observe RNA in real time using single-molecule localisation microscopy.
Blocking Treg pathway sensitises mice to immunotherapy 25 February 2021 | By Victoria Rees (Drug Target Review) Researchers have shown that inhibiting Treg activation in tumours can provide effective immune responses without autoimmune toxicity.
Nanobodies could help CRISPR turn genes on and off 25 February 2021 | By Victoria Rees (Drug Target Review) Researchers have used nanobodies to act as an assistant to CRISPR, bringing in effectors to turn specific genes on and off.
Lung and brain organoids respond differently to SARS-CoV-2 infection in lab 25 February 2021 | By Victoria Rees (Drug Target Review) Researchers have developed stem cell-derived organoids to reveal how SARS-CoV-2 interacts with lung and brain cells differently.
