Antibodies from COVID-19 vaccines less effective against SARS-CoV-2 variants 15 March 2021 | By Victoria Rees (Drug Target Review) Researchers have shown antibodies induced by the Pfizer and Moderna vaccines are less effective at neutralising certain SARS-CoV-2 variants.
Researchers reveal 3D structure responsible for gene expression 12 March 2021 | By Victoria Rees (Drug Target Review) Researchers have produced the first 3D image of the Mediator-bound pre-initiation complex, key in the regulation of gene expression.
New tool designed to add or remove sugar from proteins shows success 12 March 2021 | By Victoria Rees (Drug Target Review) Researchers have developed a new tool that can add or remove sugar from proteins, which could be used to treat currently "undruggable" targets.
Team improves non-invasive visualisation of photoreceptors in eye 12 March 2021 | By Victoria Rees (Drug Target Review) A new imaging technique for photoreceptors has been developed by selectively blocking light used to observe the eye.
Nano-micelles used in CRISPR genome editing of mouse brains 12 March 2021 | By Victoria Rees (Drug Target Review) Researchers have reported that nano-micelles can be used to efficiently deliver CRISPR-Cas9 to edit genes in the brains of mice.
Mosquito protein could hold key to therapeutics against flaviviruses 11 March 2021 | By Victoria Rees (Drug Target Review) A study has shown the mosquito protein AEG12 inhibits flaviviruses, the family of viruses that cause yellow fever, dengue and Zika.
New liver-on-a-chip model successfully mimics NAFLD 11 March 2021 | By Victoria Rees (Drug Target Review) A liver-on-a-chip model has been developed to more fully represent the natural progression of NAFLD than previous models.
Antisense oligonucleotide with potential to combat COVID-19 developed 11 March 2021 | By Victoria Rees (Drug Target Review) Scientists have designed a compound named ASO-1 that could help to reduce immune response overactivation in patients with COVID-19.
CRISPR-dead Cas9 could offer non-addictive treatment for pain, study shows 11 March 2021 | By Victoria Rees (Drug Target Review) A new CRISPR gene therapy for chronic pain has been shown in mice to temporarily repress a gene involved in sensing pain.
Potential peptide to treat multiple sclerosis passes toxicology test 10 March 2021 | By Victoria Rees (Drug Target Review) A peptide that could treat multiple sclerosis caused no neurotoxicity or cardiotoxic effects in zebrafish, a study has shown.
Study shows role IgM antibodies play in preventing thrombosis 10 March 2021 | By Victoria Rees (Drug Target Review) A new study has revealed that immunoglobulin-M antibodies recognise microvesicles, which are critical for the progression of thrombosis.
Novel spectroscopic microscope images biological molecular conformations 9 March 2021 | By Victoria Rees (Drug Target Review) A spectroscopic microscope has been developed by researchers to gather data on biological conformations faster and more accurately.
High-CBD cannabis extracts could provide COVID-19 treatment 9 March 2021 | By Victoria Rees (Drug Target Review) Cannabidiol's (CBD) anti-inflammatory properties could be harnessed to treat or prevent COVID-19, according to a new study.
New inhibitor found to combat drug-resistant cancer cells 9 March 2021 | By Victoria Rees (Drug Target Review) A team has developed a novel inhibitor that blocks a protein in cancer cells, making drug-resistant tumours respond to chemotherapy.
Analysis of proteomic data reveals potential therapeutic targets for cancer 8 March 2021 | By Victoria Rees (Drug Target Review) Researches have provided a proof-of-concept that proteomic analysis could be used to identify drivers of aggressive cancers.
