Team uses antibodies to tag disease-related proteins for destruction 19 March 2021 | By Victoria Rees (Drug Target Review) Researchers have developed a technique utilising antibodies to tag disease-causing proteins, to treat the underlying causes of disease.
Possible method to apply CAR T-cell therapy to solid tumours developed 19 March 2021 | By Victoria Rees (Drug Target Review) Researchers have developed a CAR T-cell engineering technique to ensure that only cancer cells are targeted, leaving healthy cells alone in solid tumours.
Spike protein analysis explains faster spread of SARS-CoV-2 variants 18 March 2021 | By Victoria Rees (Drug Target Review) Using cryo-electron microscopy, researchers have imaged how the SARS-CoV-2 Spike protein changes with the D614G mutation to enable faster spread of infection.
Cell-based assay developed to identify IDO1 inhibitors for immuno-oncology 18 March 2021 | By Victoria Rees (Drug Target Review) Researchers have developed a cell-based assay for the discovery of new IDO1 inhibitors, overcoming challenges from cell-free assays.
Movement of nanorobots observed in vivo using PET 18 March 2021 | By Victoria Rees (Drug Target Review) A large number of nanorobots in the bladders of mice have been visualised to reveal their movement and behaviour.
Researchers develop model of early human embryo from skin cells 18 March 2021 | By Victoria Rees (Drug Target Review) Scientists have created the first model of early human embryos by reprogramming fibroblasts into a blastocyst-like structures.
Method for analysing sugar-protein interactions could enable better biologics 17 March 2021 | By Victoria Rees (Drug Target Review) A novel machine learning method can explain how glycans stabilise proteins, aiding the discovery and design of protein-based drugs.
Study identifies potential drug target for treating COVID-19 17 March 2021 | By Victoria Rees (Drug Target Review) Researchers have shown that the PLpro coronavirus enzyme presents a possible target in the fight against COVID-19.
Machine learning calculates affinities of drug candidates and targets 16 March 2021 | By Victoria Rees (Drug Target Review) A novel machine learning method called DeepBAR could accelerate drug discovery and protein engineering, researchers say.
Researchers gain insight into metabolic pathways hijacked by SARS-CoV-2 16 March 2021 | By Victoria Rees (Drug Target Review) SARS-CoV-2 diverts building blocks from glucose production to the assembly of purine bases, researchers have found.
Nanolitre‐scale cell assays developed with droplet microarray-mass spec 16 March 2021 | By Victoria Rees (Drug Target Review) A team has developed nanolitre cell assays on droplet microarrays to enable pharmacodynamic monitoring in live cells.
Novel deep learning tool developed to analyse microscopy images 16 March 2021 | By Victoria Rees (Drug Target Review) An artificial intelligence platform has been created to enable tens of thousands of microscopy images to be generated in an hour.
Researchers reveal how key enzyme APT2 works in cells 15 March 2021 | By Victoria Rees (Drug Target Review) Using X-ray crystallography and simulations, researchers have shown that APT2 is a hybrid between a lipid carrier protein and a hydrolase.
First lab-grown mini-thyroids produced from patients’ own tissue 15 March 2021 | By Victoria Rees (Drug Target Review) Thyroid mini-organs have been generated in the lab by researchers, which are able to self-renew and differentiate into functional tissue.
RNA protein shown to protect telomeres and support cancer proliferation 15 March 2021 | By Victoria Rees (Drug Target Review) A team has revealed a function of ADAR1, responsible for RNA editing, discovering an isoform used for cancer growth, making it a drug target.
