Researchers make key discovery involved in re-engineering of peptides 11 May 2021 | By Victoria Rees (Drug Target Review) A team has characterised a key part of the peptide synthesis process, showing that only the main building block needs to be changed for re-engineering.
Second mechanism of action discovered for COVID-19 drug remdesivir 11 May 2021 | By Victoria Rees (Drug Target Review) Researchers have found that a metabolite of remdesivir potentially targets a SARS-CoV-2 protein involved in suppressing the host cell's defence response.
Applying AI to microscopy shortens image processing to seconds 10 May 2021 | By Victoria Rees (Drug Target Review) AI algorithms, light-field microscopy and light-sheet microscopy have been combined by researchers to image biological processes in 3D.
Structure of DNA actively involved in genome regulation, study shows 10 May 2021 | By Victoria Rees (Drug Target Review) Researchers have shown that topoisomerase TOP2A eliminates negative supercoiling, causing an increase in the number of turns of DNA strands and impacting gene expression.
Epithelial cells found to communicate in two distinct ways 10 May 2021 | By Victoria Rees (Drug Target Review) Epithelial cell communication depends on the side of the cell, which could have implications for understanding how cancer spreads.
Researchers use exosomes to develop potential salmonella vaccine 10 May 2021 | By Victoria Rees (Drug Target Review) Exosomes containing salmonella antigens were administered to the mice, enabling the models to develop antibodies against the bacteria.
Simulations and fragment screening reveal binding sites on tubulin protein 7 May 2021 | By Victoria Rees (Drug Target Review) A combination of computer simulations and fragment screening have uncovered 27 molecular binding sites on tubulin, a protein of the cell cytoskeleton.
Stem cell-based vaccine protects mice against pancreatic cancer 7 May 2021 | By Victoria Rees (Drug Target Review) Researchers have developed a vaccine using stem cells that protected mice injected with pancreatic cancer cells from developing tumours.
Computational epitope map of SARS-CoV-2 Spike protein developed 7 May 2021 | By Victoria Rees (Drug Target Review) Researchers have produced a computational simulation of the SARS-CoV-2 Spike protein, finding spots that glycans do not cover.
Lab of the Future to be 50 percent virtual by 2030, survey indicates 6 May 2021 | By Victoria Rees (Drug Target Review) Findings from a survey have shown 72 percent of respondents in the life sciences industry think the Lab of the Future will embrace virtual working.
Genetic profile of skeleton osteocytes mapped for first time 6 May 2021 | By Victoria Rees (Drug Target Review) Researchers have revealed which genes are switched on or off in osteocytes, a bone cell found in the skeleton.
Lead compound to potentially treat pulmonary arterial hypertension found 6 May 2021 | By Victoria Rees (Drug Target Review) After screening 4,500 compounds using induced pluripotent stem cells, researchers have identified one lead that could treat pulmonary arterial hypertension.
Team identifies paediatric acute myeloid leukaemia drug target 6 May 2021 | By Victoria Rees (Drug Target Review) Researchers have found that the gene mesothelin can be targeted by new antibody-drug conjugates to treat acute myeloid leukaemia in children.
UK Government funds facility to test vaccines against COVID-19 variants 5 May 2021 | By Victoria Rees (Drug Target Review) The UK Government will invest £29.3 million to test the effectiveness of COVID-19 vaccines against variants in 3,000 blood samples a week.
Gene therapy in Alzheimer’s mouse model preserves learning and memory 5 May 2021 | By Victoria Rees (Drug Target Review) A new gene therapy that introduced SynCav1 to the brains of Alzheimer's mouse models was shown to preserve neuronal and synaptic plasticity.
