Researchers identify how to potentially prevent cancer metastases 3 June 2021 | By Victoria Rees (Drug Target Review) Scientists have discovered that hepatic stellate cells are key in allowing dormant cancer cells to awaken and form fatal metastases.
High-throughput screening platform detects henipavirus antivirals 3 June 2021 | By Victoria Rees (Drug Target Review) A new high-throughput screening platform has been used to identify two compounds with antiviral activity against the Nipah and Hendra viruses.
Method for high-throughput RNA sequencing in single cells developed 2 June 2021 | By Victoria Rees (Drug Target Review) A new method named scifi-RNA-seq marks the RNA of cells with specific barcodes, enabling the sequencing of many cells at the same time.
RT-ddPCR assay developed to quantify regions of SARS-CoV-2 RNA 2 June 2021 | By Victoria Rees (Drug Target Review) Scientists have created a RT-ddPCR assay to analyse both the non-coding and coding RNA regions of SARS-CoV-2.
Fluorescence technique developed to image living brain at capillary level 1 June 2021 | By Victoria Rees (Drug Target Review) A new non-invasive microscopic fluorescence imaging method has been developed to reveal details of the brain in animal models of various diseases.
Novel DNA vaccine for SARS-CoV-2 effective in rodent models 1 June 2021 | By Victoria Rees (Drug Target Review) A new DNA vaccine encoding the SARS-CoV-2 Spike protein has shown promise at protecting mice and hamsters against COVID-19.
New immunosensor developed for use in immunoassays 31 May 2021 | By Victoria Rees (Drug Target Review) A modified luciferase enzyme has been developed as an immunosensor to be fused with a Q-body and used in immunoassays.
Cross-reactive antibody could form basis of broad coronavirus vaccine 28 May 2021 | By Victoria Rees (Drug Target Review) Researchers have discovered a cross-reactive coronavirus antibody that could aid in the development of a broad-acting vaccine or treatment.
Drug target to halt progression of Parkinson’s disease identified 28 May 2021 | By Victoria Rees (Drug Target Review) Scientists have shown that trapped LC3B protein in brain cells enables Parkinson's disease to spread, presenting a drug target.
Inhaled nanobodies effective against SARS-CoV-2 in hamsters 27 May 2021 | By Victoria Rees (Drug Target Review) Researchers have shown that inhalable nanobodies at ultra-low doses can effectively neutralise SARS-CoV-2 in hamsters.
Non-opioid based target identified to potentially treat chronic pain 27 May 2021 | By Victoria Rees (Drug Target Review) Researchers have discovered that blocking TRPC5 activity treated chronic pain in mouse models of various conditions.
Computational method developed to map chromosome folding in 3D 27 May 2021 | By Victoria Rees (Drug Target Review) Researchers created their new method to analyse chromosomes in 3D, revealing how misconfigurations play a role in cancer.
SARS-CoV-2 RNA analysis reveals potential treatment targets 26 May 2021 | By Victoria Rees (Drug Target Review) Researchers have explored the interaction between SARS-CoV-2 RNA and the host cell, uncovering possible targets to prevent viral replication.
Analogue of psychedelic ibogaine reverses effects of stress in mice 26 May 2021 | By Victoria Rees (Drug Target Review) Tabernanthalog (TBG), similar to the psychedelic drug ibogaine, corrected stress-induced behavioural deficits in mice.
Researchers synthesise potential anticancer compounds 26 May 2021 | By Victoria Rees (Drug Target Review) Scientists have developed six new derivatives of 4-chloro-1,2-dithiol-3-thione, which have all demonstrated anticancer effects in pre-clinical studies.
