Combination therapy suppresses HIV-like virus in primates
Broadly neutralising antibody treatment may target viral reservoir in monkeys...
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Scientists develop novel method for membrane protein crystallisation
Scientists in Switzerland have developed a new means of crystallising membrane proteins – a hitherto elusive feat – in order to study their structure and aid understanding of their processes.
Researchers create enhanced nanoscaffold for regenerative heart medicine
Biophysicists in Russia have gained greater understanding about the structure of nanofibrous scaffolds – termed nanoscaffolds – in a study that is researching heart tissue regeneration.
Kenpaullone protects from cisplatin-induced hearing loss
Researchers have discovered that inhibiting an enzyme called cyclin-dependent kinase 2 protects mice and rats from noise- or drug-induced hearing loss...
EGFL7 protein provides a new treatment approach for MS
Researchers have discovered that the EGFL7 protein inhibits the migration of immune cells into the brain...
Preventing exhaustion in immune cells boosts immunotherapy in mice
Research shows that preventing or reversing ‘T-cell exhaustion’ with targeted therapies could enhance the effects of immunotherapy.
μCENSE platform isolates diseased circulating biomarkers
A new liquid biopsy platform has been developed to isolate circulating disease biomarkers...
Paediatric Clinical Trials
When designing a Paediatric clinical trial, a paediatric investigation plan (PIP) is a development plan aimed at ensuring that the necessary data are obtained through studies in children, to support the authorisation of a medicine for children...
Splicing-variant detection method identifies biomarkers for HCC
Researchers report a method for identifying splicing-based biomarkers for hepatocellular carcinoma....
Blockade of MT4-MMP protease increases blood-patrolling monocyte activity
Researchers in Spain have identified a function of the MT4-MMP protease (an enzyme that breaks down proteins) that could be targeted as a potential treatment for some infections, as well as tumour metastasis.
Scientists create complex transmembrane proteins from scratch
Advance paves the way for the design of transmembrane proteins with useful new functions...
Change in neuron size could shed light on new treatments for ALS
Understanding how motor nerve cells respond to motor neurone disease could help researchers identify new treatment options...
Researchers find transferable antibiotic resistance gene in pathogen of developing nations
A team of investigators has found that the mcr-1 drug resistance gene, which encodes resistance to a drug that is used as a last resort, has been found for the first time in Shigella flexneri.
Scientists advocate less toxic treatment for rare leukaemia (MPAL)
Researchers in the US have undertaken meta-analysis studies to ascertain the optimum approach for doctors treating rare mixed phenotype acute leukaemia (MPAL). They found that a less-toxic regimen gives better results.
Scientists find that dectin-1 receptor protects against allergies
Contrary to previous notions that the receptor dectin-1 causes allergic reactions, new research from the John Hopkins Bloomberg School of Public Health has found that it actually prevents this response, indicating new targets for allergy and asthma drugs.
