Migraine study provides insight into the disease 8 May 2018 | By Drug Target Review By studying migraine patients researchers have identified over 40 significant genetic risk variants that predispose individuals to migraines...
CAR-T immunotherapy eliminates metastatic colorectal cancer in mice 8 May 2018 | By Dr Zara Kassam (Drug Target Review) A CAR-T-based immunotherapy successfully kills tumours and prevents metastatic growth, in final preclinical tests before human trials...
Study offers new approach to starve p53 deficient tumours 7 May 2018 | By Drug Target Review Sanford Prebys Medical Discovery Institute (SBP) researchers recently discovered an alternative metabolic pathway that might be used by cancer cells to survive nutrient deprivation.
Controlling immune cell migration as therapy for heart disease 7 May 2018 | By Drug Target Review Researchers in the United States find that the location of the body’s immune cells correlates precisely with their function related to heart disease.
Scientists study long-term effects of stem cell treatment for AICLI 4 May 2018 | By Drug Target Review Researchers in China have conducted a unique study investigating the long-term effects of stem cells to treat angiitis-induced critical limb ischemia (AICLI).
Lymphatic endothelial cells are found to promote the spread of melanoma 4 May 2018 | By Drug Target Review Scientists have investigated the mechanisms by which the lymphatic endothelial cells modulate metastasis in melanoma, providing new targets for therapy development.
Research identifies novel unconventional type of immune cell capable of fighting viral infections 4 May 2018 | By Drug Target Review Research led by the University of Birmingham has identified a novel unconventional type of immune cell capable of fighting viral infections.
Genomic analysis unravels complexities of the most common form of lymphoma 3 May 2018 | By Drug Target Review Genomic analysis has shown a better framework for understanding lymphoma’s many forms and will help to predict individual patient outcomes and guide personalised treatment.
T cell populations in CLL patients indicate potential success of CAR-T cell therapy 3 May 2018 | By Drug Target Review Researchers have discovered the reason why some patients with advanced chronic lymphocytic leukaemia (CLL) don't respond to chimeric antigen receptor (CAR) T cell therapy...
Scientists find possible autism biomarker in cerebrospinal fluid 3 May 2018 | By Drug Target Review Researchers have found that low vasopressin in the cerebrospinal fluid may be a biomarker for autism...
FoxM1 gene provides promising target for pulmonary hypertension 2 May 2018 | By Dr Zara Kassam (Drug Target Review) The FoxM1 gene will drive the development of new drugs to reverse a process called vascular remodelling - a key feature in pulmonary hypertension...
New insights into the origins of mutations in cancer 2 May 2018 | By Drug Target Review Scientists use data from human cancers and C. elegans to understand mutational causes of cancer...
Therapeutic RNA corrects splicing defect that causes familial dysautonomia 2 May 2018 | By Dr Zara Kassam (Drug Target Review) Scientists have identified a therapeutic RNA molecule that corrects the error in genetic processing that leads to familial dysautonomia...
UFD1 protein responsible for aggressive leukaemia 1 May 2018 | By Dr Zara Kassam (Drug Target Review) Researchers have identified a protein critical for the aggressiveness of T-cell leukaemia...
CRISPR used to improve red blood cell transfusion compatibility 1 May 2018 | By Dr Zara Kassam (Drug Target Review) Scientists have created individual cell lines in which specific blood group genes were altered to prevent the expression of blood group proteins...
