Novel mRNA vaccine provides full protection against malaria in mice 21 June 2021 | By Victoria Rees (Drug Target Review) A new mRNA vaccine based on the malaria circumsporozoite protein was shown to elicit a robust immune response in mice.
Nanodecoy therapy neutralises SARS-CoV-2 in macaques 18 June 2021 | By Victoria Rees (Drug Target Review) Lung spheroid cells can act as nanodecoys for the SARS-CoV-2 Spike protein to bind to, according to a new pre-clinical study.
Researchers visualise metabolic processes at the single-cell level 18 June 2021 | By Victoria Rees (Drug Target Review) Scientists have used imaging methods and machine learning to understand cellular metabolism at the single-cell level.
High-throughput screening protocol created to discover SHP2 inhibitors 18 June 2021 | By Victoria Rees (Drug Target Review) Researchers have developed a cross-validation high-throughput screening method to accelerate the identification of SHP2 inhibitors.
New approach for treating cystic fibrosis shows success in mice 17 June 2021 | By Victoria Rees (Drug Target Review) Researchers have developed a potential strategy to treat cystic fibrosis, using oligonucleotides to correct certain gene defects.
Stem cells may be key for new vaccines against COVID-19 17 June 2021 | By Victoria Rees (Drug Target Review) Scientists say COVID-19 may activate tuberculosis infection, but stem cell-mediated defence mechanisms could be targeted to develop vaccines.
Scientists use stem cells to generate rudimentary kidney organoids 16 June 2021 | By Victoria Rees (Drug Target Review) Researchers have developed kidney organoids that resemble the collecting duct system, using ureteric bud progenitor cells.
Researchers 3D print rotating microfilter for lab-on-a-chip applications 16 June 2021 | By Victoria Rees (Drug Target Review) A new magnetically driven rotary microfilter has been developed to filter particles inside a lab-on-a-chip microfluidic device.
Two COVID-19 vaccines show safety and strong immunity in infant model 16 June 2021 | By Victoria Rees (Drug Target Review) Two groups of infant rhesus macaques received one of two potential COVID-19 vaccines, which were shown to elicit high levels of neutralising antibodies.
Radiopharmaceuticals and nanoparticles used to kill cancer cells 15 June 2021 | By Victoria Rees (Drug Target Review) Researchers have developed a potential cancer treatment using light from radiopharmaceuticals and polymer nanoparticles to kill cancer cells.
Reference genome comparison finds exome variant discrepancies 15 June 2021 | By Victoria Rees (Drug Target Review) Scientists have found differences in 206 genes between the GRCh38 (hg38) and GRCh37 (hg19) human reference genomes.
Targeted drug found to combat certain pancreatic tumours 15 June 2021 | By Victoria Rees (Drug Target Review) Researchers have found that the CDK inhibitor AT7519 could be used to treat pancreatic cancer patients whose tumours are addicted to mutant KRAS.
Human cells can write RNA sequences into DNA, study shows 14 June 2021 | By Victoria Rees (Drug Target Review) For the first time, scientists have found evidence that polymerase theta can write RNA segments back into DNA.
Potential ovarian cancer treatment proves effective in pre-clinical studies 14 June 2021 | By Victoria Rees (Drug Target Review) A new radiopharmaceutical compound has shown success at treating ovarian cancer in mice and in vitro studies.
Study provides clues to cause and possible treatment of Parkinson’s 14 June 2021 | By Victoria Rees (Drug Target Review) Researchers have shown that the leakage of mitochondrial double-stranded DNA into the cell can contribute to Parkinson's disease.
