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Gene signature holds promise for early detection of active TB

20 June 2018 | By Drug Target Review

A gene signature in the bloodstream could reveal whether someone is going to develop active tuberculosis (TB) disease months before symptoms begin.

Breast cancer could be prevented by targeting epigenetic proteins

20 June 2018 | By Drug Target Review

Researchers have discovered that epigenetic proteins promote the proliferation of mammary gland stem cells in response to the sex hormone progesterone.

RNA-Seq assay can detect gene fusions in solid tumour cells

19 June 2018 | By Drug Target Review

Using the RNA-Seq assay to detect gene fusions can improve the diagnosis and targeted treatment of solid tumors, reports The Journal of Molecular Diagnostics

Microglia protect sensory cells needed for vision after retinal detachment

19 June 2018 | By Drug Target Review

New research shows that microglia, immune cells of the brain and retina, play a protective role in response to retinal detachment...

CRISPR technology may improve accuracy of predicting heart disease risk

19 June 2018 | By Dr Zara Kassam (Drug Target Review)

Scientists may now be able to predict whether carrying a specific genetic variant increases a person's risk for disease using gene editing and stem cell technologies...

Targeting BAFF reduces the development of atherosclerosis

18 June 2018 | By Drug Target Review

The researchers identified that BAFF to have anti-inflammatory properties, which has a positive effect on plaque size and atherosclerosis...

Platypus venom inspires potential new diabetes treatments

18 June 2018 | By Drug Target Review

A metabolic hormone found in the venom and gut of Australia’s iconic platypus will now be investigated for its potential to treat type 2 diabetes...

New evidence sheds light on how Parkinson’s disease may happen

18 June 2018 | By Drug Target Review

Researchers at Baylor College of Medicine and Texas Children’s Hospital have identified unexpected new key players in the development of an early onset form of Parkinson’s disease called Parkinsonism.

The loss of CDK12 pinpoints to a new sub-type of prostate cancer

15 June 2018 | By Drug Target Review

Tumours with alterations in the CDK12 gene were more responsive to immunotherapy, suggesting precision medicine approach...

Genetically engineered bacteria show promise as a new treatment for constipation

15 June 2018 | By Drug Target Review

Researchers have genetically engineered bacteria as a potential new treatment for constipation, the finding is significant in part because there are few approved constipation remedies on the market...

Pyroptosis brain cell death identified as novel pathway for MS treatment

15 June 2018 | By Drug Target Review

Researchers at the University of Alberta in Canada have discovered a unique process of brain cell death called pyroptosis that affects the cells that are most vulnerable in multiple sclerosis (MS).

Cancer protein NEDD9 plays a critical role in PAH

14 June 2018 | By Dr Zara Kassam (Drug Target Review)

Study identifies cancer protein as a target for treating fibrosis of the lung arteries with direct implications for patients with pulmonary arterial hypertension...

Alpha-synuclein clumps promote Parkinson’s progression

14 June 2018 | By Dr Zara Kassam (Drug Target Review)

Detailed brain cell analysis has helped researchers uncover new mechanisms thought to underlie Parkinson's disease...

A new therapy proves effective against brain metastasis

14 June 2018 | By Drug Target Review

The administration of silibinin in patients with brain metastasis reduces lesions without causing any adverse effects, according to a study led by researchers at the Spanish National Cancer Research Centre (CNIO).

New target for treating heart failure identified by Penn Medicine researchers

13 June 2018 | By Drug Target Review

Reversing modifications in diseased heart muscle cell struts called microtubules (MT) can lessen the stiffness and improve the beating strength of these cells isolated from transplant patients with heart failure.

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